PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study.
Identifieur interne : 000653 ( PubMed/Checkpoint ); précédent : 000652; suivant : 000654PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study.
Auteurs : Amand F. Schmidt [Royaume-Uni] ; Daniel I. Swerdlow [Royaume-Uni] ; Michael V. Holmes [Royaume-Uni] ; Riyaz S. Patel [Royaume-Uni] ; Zammy Fairhurst-Hunter [Royaume-Uni] ; Donald M. Lyall [Royaume-Uni] ; Fernando Pires Hartwig [Brésil] ; Bernardo Lessa Horta [Brésil] ; Elina Hyppönen [Australie] ; Christine Power [Royaume-Uni] ; Max Moldovan [Australie] ; Erik Van Iperen [Pays-Bas] ; G Kees Hovingh [Pays-Bas] ; Ilja Demuth [Allemagne] ; Kristina Norman [Allemagne] ; Elisabeth Steinhagen-Thiessen [Allemagne] ; Juri Demuth [Allemagne] ; Lars Bertram [Allemagne] ; Tian Liu [Allemagne] ; Stefan Coassin [Autriche] ; Johann Willeit [Autriche] ; Stefan Kiechl [Autriche] ; Karin Willeit [Autriche] ; Dan Mason [Royaume-Uni] ; John Wright [Royaume-Uni] ; Richard Morris [Royaume-Uni] ; Goya Wanamethee [Royaume-Uni] ; Peter Whincup [Royaume-Uni] ; Yoav Ben-Shlomo [Royaume-Uni] ; Stela Mclachlan [Royaume-Uni] ; Jackie F. Price [Royaume-Uni] ; Mika Kivimaki [Royaume-Uni] ; Catherine Welch [Royaume-Uni] ; Adelaida Sanchez-Galvez [Royaume-Uni] ; Pedro Marques-Vidal [Suisse] ; Andrew Nicolaides [Chypre (pays)] ; Andrie G. Panayiotou [Chypre (pays)] ; N Charlotte Onland-Moret [Pays-Bas] ; Yvonne T. Van Der Schouw [Pays-Bas] ; Giuseppe Matullo [Italie] ; Giovanni Fiorito [Italie] ; Simonetta Guarrera [Italie] ; Carlotta Sacerdote [Italie] ; Nicholas J. Wareham [Royaume-Uni] ; Claudia Langenberg [Royaume-Uni] ; Robert Scott [Royaume-Uni] ; Jian'An Luan [Royaume-Uni] ; Martin Bobak [Royaume-Uni] ; Sofia Malyutina [Russie] ; Andrzej Paj K [Pologne] ; Ruzena Kubinova [République tchèque] ; Abdonas Tamosiunas [Lituanie] ; Hynek Pikhart [Royaume-Uni] ; Lise Lotte Nystrup Husemoen [Danemark] ; Niels Grarup [Danemark] ; Oluf Pedersen [Danemark] ; Torben Hansen [Danemark] ; Allan Linneberg [Danemark] ; Kenneth Starup Simonsen [Danemark] ; Jackie Cooper [Royaume-Uni] ; Steve E. Humphries [Royaume-Uni] ; Murray Brilliant [États-Unis] ; Terrie Kitchner [États-Unis] ; Hakon Hakonarson [États-Unis] ; David S. Carrell [États-Unis] ; Catherine A. Mccarty [États-Unis] ; H Lester Kirchner [États-Unis] ; Eric B. Larson [États-Unis] ; David R. Crosslin [États-Unis] ; Mariza De Andrade [États-Unis] ; Dan M. Roden [États-Unis] ; Joshua C. Denny [États-Unis] ; Cara Carty [États-Unis] ; Stephen Hancock [Australie] ; John Attia [Australie] ; Elizabeth Holliday [Australie] ; Martin O'Donnell [Canada] ; Salim Yusuf [Canada] ; Michael Chong [Canada] ; Guillaume Pare [Canada] ; Pim Van Der Harst [Pays-Bas] ; M Abdullah Said [Pays-Bas] ; Ruben N. Eppinga [Pays-Bas] ; Niek Verweij [Pays-Bas] ; Harold Snieder [Pays-Bas] ; Tim Christen [Pays-Bas] ; Dennis O. Mook-Kanamori [Pays-Bas] ; Stefan Gustafsson [Suède] ; Lars Lind [Suède] ; Erik Ingelsson [États-Unis] ; Raha Pazoki [Pays-Bas] ; Oscar Franco [Pays-Bas] ; Albert Hofman [Pays-Bas] ; Andre Uitterlinden [Pays-Bas] ; Abbas Dehghan [Pays-Bas] ; Alexander Teumer [Allemagne] ; Sebastian Baumeister [Allemagne] ; Marcus Dörr [Allemagne] ; Markus M. Lerch [Allemagne] ; Uwe Völker [Allemagne] ; Henry Völzke [Allemagne] ; Joey Ward [Royaume-Uni] ; Jill P. Pell [Royaume-Uni] ; Daniel J. Smith [Royaume-Uni] ; Tom Meade [Royaume-Uni] ; Anke H. Maitland-Van Der Zee [Pays-Bas] ; Ekaterina V. Baranova [Pays-Bas] ; Robin Young [Royaume-Uni] ; Ian Ford [Royaume-Uni] ; Archie Campbell [Royaume-Uni] ; Sandosh Padmanabhan [Royaume-Uni] ; Michiel L. Bots [Pays-Bas] ; Diederick E. Grobbee [Pays-Bas] ; Philippe Froguel [France] ; Dorothée Thuillier [France] ; Beverley Balkau [France] ; Amélie Bonnefond [France] ; Bertrand Cariou [France] ; Melissa Smart [Royaume-Uni] ; Yanchun Bao [Royaume-Uni] ; Meena Kumari [Royaume-Uni] ; Anubha Mahajan [Royaume-Uni] ; Paul M. Ridker [États-Unis] ; Daniel I. Chasman [États-Unis] ; Alex P. Reiner [États-Unis] ; Leslie A. Lange [États-Unis] ; Marylyn D. Ritchie [États-Unis] ; Folkert W. Asselbergs [Pays-Bas] ; Juan-Pablo Casas [Royaume-Uni] ; Brendan J. Keating [États-Unis] ; David Preiss [Royaume-Uni] ; Aroon D. Hingorani [Royaume-Uni] ; Naveed Sattar [Royaume-Uni]Source :
- The lancet. Diabetes & endocrinology [ 2213-8595 ] ; 2017.
Abstract
Statin treatment and variants in the gene encoding HMG-CoA reductase are associated with reductions in both the concentration of LDL cholesterol and the risk of coronary heart disease, but also with modest hyperglycaemia, increased bodyweight, and modestly increased risk of type 2 diabetes, which in no way offsets their substantial benefits. We sought to investigate the associations of LDL cholesterol-lowering PCSK9 variants with type 2 diabetes and related biomarkers to gauge the likely effects of PCSK9 inhibitors on diabetes risk.
DOI: 10.1016/S2213-8587(16)30396-5
PubMed: 27908689
Affiliations:
- Allemagne, Australie, Autriche, Brésil, Canada, Chypre (pays), Danemark, France, Italie, Lituanie, Pays-Bas, Pologne, Royaume-Uni, Russie, République tchèque, Suisse, Suède, États-Unis
- Angleterre, Berlin, Bohême centrale, Californie, Canton de Vaud, Colorado, District de Columbia, East Middle Sweden, Grand Londres, Groningue (province), Hauts-de-France, Hollande-Méridionale, Hovedstaden, Massachusetts, Minnesota, Nord-Pas-de-Calais, Oxfordshire, Pays de la Loire, Pennsylvanie, Piémont, Svealand, Tennessee, Tyrol (Land), Utrecht (province), Washington (État), Wisconsin, Écosse
- Berlin, Copenhague, Glasgow, Groningue, Innsbruck, Lausanne, Leyde, Lille, Londres, Nantes, Oxford, Prague, Rotterdam, Seattle, Turin, University Park (Pennsylvanie), Uppsala, Utrecht, Édimbourg
- University College de Londres, Université d'Oxford, Université d'Uppsala, Université d'Utrecht, Université d'Édimbourg, Université d'État de Pennsylvanie, Université de Glasgow, Université de Londres, Université de Washington, Université de médecine d'Innsbruck
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Institutes of Neurogenetics and Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Neuroepidemiology and Ageing Research Unit, Imperial College London, London, UK; Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), Institutes of Neurogenetics and Integrative and Experimental Genomics, University of Lübeck, Lübeck</wicri:regionArea><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Tian" sort="Liu, Tian" uniqKey="Liu T" first="Tian" last="Liu">Tian Liu</name><affiliation wicri:level="3"><nlm:affiliation>Max Planck Institute for Human Development, Berlin, Germany; Max Planck Institute for Molecular Genetics, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max Planck Institute for Human Development, Berlin, Germany; Max Planck Institute for Molecular Genetics, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Coassin, Stefan" sort="Coassin, Stefan" uniqKey="Coassin S" first="Stefan" last="Coassin">Stefan Coassin</name><affiliation wicri:level="4"><nlm:affiliation>Division of Genetic Epidemiology Innsbruck, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Division of Genetic Epidemiology Innsbruck, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck</wicri:regionArea><orgName type="university">Université de médecine d'Innsbruck</orgName><placeName><settlement type="city">Innsbruck</settlement><region nuts="2" type="region">Tyrol (Land)</region></placeName></affiliation></author><author><name sortKey="Willeit, Johann" sort="Willeit, Johann" uniqKey="Willeit J" first="Johann" last="Willeit">Johann Willeit</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University of Innsbruck, Innsbruck</wicri:regionArea><orgName type="university">Université de médecine d'Innsbruck</orgName><placeName><settlement type="city">Innsbruck</settlement><region nuts="2" type="region">Tyrol (Land)</region></placeName></affiliation></author><author><name sortKey="Kiechl, Stefan" sort="Kiechl, Stefan" uniqKey="Kiechl S" first="Stefan" last="Kiechl">Stefan Kiechl</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University of Innsbruck, Innsbruck</wicri:regionArea><orgName type="university">Université de médecine d'Innsbruck</orgName><placeName><settlement type="city">Innsbruck</settlement><region nuts="2" type="region">Tyrol (Land)</region></placeName></affiliation></author><author><name sortKey="Willeit, Karin" sort="Willeit, Karin" uniqKey="Willeit K" first="Karin" last="Willeit">Karin Willeit</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University of Innsbruck, Innsbruck</wicri:regionArea><orgName type="university">Université de médecine d'Innsbruck</orgName><placeName><settlement type="city">Innsbruck</settlement><region nuts="2" type="region">Tyrol (Land)</region></placeName></affiliation></author><author><name sortKey="Mason, Dan" sort="Mason, Dan" uniqKey="Mason D" first="Dan" last="Mason">Dan Mason</name><affiliation wicri:level="1"><nlm:affiliation>Bradford Institute for Health Research, Bradford Royal Infirmary, Bradford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Bradford Institute for Health Research, Bradford Royal Infirmary, Bradford</wicri:regionArea><wicri:noRegion>Bradford</wicri:noRegion></affiliation></author><author><name sortKey="Wright, John" sort="Wright, John" uniqKey="Wright J" first="John" last="Wright">John Wright</name><affiliation wicri:level="1"><nlm:affiliation>Bradford Institute for Health Research, Bradford Royal Infirmary, Bradford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Bradford Institute for Health Research, Bradford Royal Infirmary, Bradford</wicri:regionArea><wicri:noRegion>Bradford</wicri:noRegion></affiliation></author><author><name sortKey="Morris, Richard" sort="Morris, Richard" uniqKey="Morris R" first="Richard" last="Morris">Richard Morris</name><affiliation wicri:level="1"><nlm:affiliation>School of Social and Community Medicine, University of Bristol, Bristol, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Wanamethee, Goya" sort="Wanamethee, Goya" uniqKey="Wanamethee G" first="Goya" last="Wanamethee">Goya Wanamethee</name><affiliation wicri:level="4"><nlm:affiliation>Department of Primary Care & Population Health, University College London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Primary Care & Population Health, University College London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Whincup, Peter" sort="Whincup, Peter" uniqKey="Whincup P" first="Peter" last="Whincup">Peter Whincup</name><affiliation wicri:level="4"><nlm:affiliation>Population Health Research Institute, St George's, University of London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Population Health Research Institute, St George's, University of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Ben Shlomo, Yoav" sort="Ben Shlomo, Yoav" uniqKey="Ben Shlomo Y" first="Yoav" last="Ben-Shlomo">Yoav Ben-Shlomo</name><affiliation wicri:level="1"><nlm:affiliation>School of Social and Community Medicine, University of Bristol, Bristol, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Mclachlan, Stela" sort="Mclachlan, Stela" uniqKey="Mclachlan S" first="Stela" last="Mclachlan">Stela Mclachlan</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh</wicri:regionArea><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region><settlement type="city">Édimbourg</settlement></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Price, Jackie F" sort="Price, Jackie F" uniqKey="Price J" first="Jackie F" last="Price">Jackie F. Price</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh</wicri:regionArea><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region><settlement type="city">Édimbourg</settlement></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Kivimaki, Mika" sort="Kivimaki, Mika" uniqKey="Kivimaki M" first="Mika" last="Kivimaki">Mika Kivimaki</name><affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Welch, Catherine" sort="Welch, Catherine" uniqKey="Welch C" first="Catherine" last="Welch">Catherine Welch</name><affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Sanchez Galvez, Adelaida" sort="Sanchez Galvez, Adelaida" uniqKey="Sanchez Galvez A" first="Adelaida" last="Sanchez-Galvez">Adelaida Sanchez-Galvez</name><affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Marques Vidal, Pedro" sort="Marques Vidal, Pedro" uniqKey="Marques Vidal P" first="Pedro" last="Marques-Vidal">Pedro Marques-Vidal</name><affiliation wicri:level="3"><nlm:affiliation>Internal Medicine Unit, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Internal Medicine Unit, Department of Medicine, Lausanne University Hospital, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Nicolaides, Andrew" sort="Nicolaides, Andrew" uniqKey="Nicolaides A" first="Andrew" last="Nicolaides">Andrew Nicolaides</name><affiliation wicri:level="1"><nlm:affiliation>Department of Vascular Surgery, Imperial College London, London, UK; Department of Surgery, Nicosia Medical School, University of Nicosia, Nicosia, Cyprus.</nlm:affiliation><country xml:lang="fr">Chypre (pays)</country><wicri:regionArea>Department of Vascular Surgery, Imperial College London, London, UK; Department of Surgery, Nicosia Medical School, University of Nicosia, Nicosia</wicri:regionArea><wicri:noRegion>Nicosia</wicri:noRegion></affiliation></author><author><name sortKey="Panayiotou, Andrie G" sort="Panayiotou, Andrie G" uniqKey="Panayiotou A" first="Andrie G" last="Panayiotou">Andrie G. Panayiotou</name><affiliation wicri:level="1"><nlm:affiliation>Cyprus International Institute for Environmental and Public Health, Cyprus University of Technology, Limassol, Cyprus.</nlm:affiliation><country xml:lang="fr">Chypre (pays)</country><wicri:regionArea>Cyprus International Institute for Environmental and Public Health, Cyprus University of Technology, Limassol</wicri:regionArea><wicri:noRegion>Limassol</wicri:noRegion></affiliation></author><author><name sortKey="Onland Moret, N Charlotte" sort="Onland Moret, N Charlotte" uniqKey="Onland Moret N" first="N Charlotte" last="Onland-Moret">N Charlotte Onland-Moret</name><affiliation wicri:level="3"><nlm:affiliation>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Van Der Schouw, Yvonne T" sort="Van Der Schouw, Yvonne T" uniqKey="Van Der Schouw Y" first="Yvonne T" last="Van Der Schouw">Yvonne T. Van Der Schouw</name><affiliation wicri:level="3"><nlm:affiliation>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Matullo, Giuseppe" sort="Matullo, Giuseppe" uniqKey="Matullo G" first="Giuseppe" last="Matullo">Giuseppe Matullo</name><affiliation wicri:level="3"><nlm:affiliation>Human Genetics Foundation, HuGeF, Turin, Italy; Department of Medical Sciences, University of Turin, Turin, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Human Genetics Foundation, HuGeF, Turin, Italy; Department of Medical Sciences, University of Turin, Turin</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Fiorito, Giovanni" sort="Fiorito, Giovanni" uniqKey="Fiorito G" first="Giovanni" last="Fiorito">Giovanni Fiorito</name><affiliation wicri:level="3"><nlm:affiliation>Human Genetics Foundation, HuGeF, Turin, Italy; Department of Medical Sciences, University of Turin, Turin, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Human Genetics Foundation, HuGeF, Turin, Italy; Department of Medical Sciences, University of Turin, Turin</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Guarrera, Simonetta" sort="Guarrera, Simonetta" uniqKey="Guarrera S" first="Simonetta" last="Guarrera">Simonetta Guarrera</name><affiliation wicri:level="3"><nlm:affiliation>Human Genetics Foundation, HuGeF, Turin, Italy; Department of Medical Sciences, University of Turin, Turin, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Human Genetics Foundation, HuGeF, Turin, Italy; Department of Medical Sciences, University of Turin, Turin</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Sacerdote, Carlotta" sort="Sacerdote, Carlotta" uniqKey="Sacerdote C" first="Carlotta" last="Sacerdote">Carlotta Sacerdote</name><affiliation wicri:level="3"><nlm:affiliation>Cancer Epidemiology Unit, San Giovanni Battista Hospital, Turin, Italy; Centre for Oncology Prevention, CPO Piemonte, Turin, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Cancer Epidemiology Unit, San Giovanni Battista Hospital, Turin, Italy; Centre for Oncology Prevention, CPO Piemonte, Turin</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J" last="Wareham">Nicholas J. Wareham</name><affiliation wicri:level="1"><nlm:affiliation>MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Langenberg, Claudia" sort="Langenberg, Claudia" uniqKey="Langenberg C" first="Claudia" last="Langenberg">Claudia Langenberg</name><affiliation wicri:level="1"><nlm:affiliation>MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Scott, Robert" sort="Scott, Robert" uniqKey="Scott R" first="Robert" last="Scott">Robert Scott</name><affiliation wicri:level="1"><nlm:affiliation>MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Luan, Jian An" sort="Luan, Jian An" uniqKey="Luan J" first="Jian'An" last="Luan">Jian'An Luan</name><affiliation wicri:level="1"><nlm:affiliation>MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Bobak, Martin" sort="Bobak, Martin" uniqKey="Bobak M" first="Martin" last="Bobak">Martin Bobak</name><affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Malyutina, Sofia" sort="Malyutina, Sofia" uniqKey="Malyutina S" first="Sofia" last="Malyutina">Sofia Malyutina</name><affiliation wicri:level="1"><nlm:affiliation>Novosibirsk State Medical University, Novosibirsk, Russia; Institute of Internal and Preventive Medicine, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Novosibirsk State Medical University, Novosibirsk, Russia; Institute of Internal and Preventive Medicine, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk</wicri:regionArea><wicri:noRegion>Novosibirsk</wicri:noRegion></affiliation></author><author><name sortKey="Paj K, Andrzej" sort="Paj K, Andrzej" uniqKey="Paj K A" first="Andrzej" last="Paj K">Andrzej Paj K</name><affiliation wicri:level="1"><nlm:affiliation>Jagiellonian University Collegium Medicum, Krakow, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Jagiellonian University Collegium Medicum, Krakow</wicri:regionArea><wicri:noRegion>Krakow</wicri:noRegion></affiliation></author><author><name sortKey="Kubinova, Ruzena" sort="Kubinova, Ruzena" uniqKey="Kubinova R" first="Ruzena" last="Kubinova">Ruzena Kubinova</name><affiliation wicri:level="3"><nlm:affiliation>National Institute of Public Health, Prague, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>National Institute of Public Health, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Tamosiunas, Abdonas" sort="Tamosiunas, Abdonas" uniqKey="Tamosiunas A" first="Abdonas" last="Tamosiunas">Abdonas Tamosiunas</name><affiliation wicri:level="1"><nlm:affiliation>Lithuanian University of Health Sciences, Kaunas, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Lithuanian University of Health Sciences, Kaunas</wicri:regionArea><wicri:noRegion>Kaunas</wicri:noRegion></affiliation></author><author><name sortKey="Pikhart, Hynek" sort="Pikhart, Hynek" uniqKey="Pikhart H" first="Hynek" last="Pikhart">Hynek Pikhart</name><affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Husemoen, Lise Lotte Nystrup" sort="Husemoen, Lise Lotte Nystrup" uniqKey="Husemoen L" first="Lise Lotte Nystrup" last="Husemoen">Lise Lotte Nystrup Husemoen</name><affiliation wicri:level="1"><nlm:affiliation>Research Centre for Prevention and Health, Capital Region of Denmark, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Research Centre for Prevention and Health, Capital Region of Denmark</wicri:regionArea><wicri:noRegion>Capital Region of Denmark</wicri:noRegion></affiliation></author><author><name sortKey="Grarup, Niels" sort="Grarup, Niels" uniqKey="Grarup N" first="Niels" last="Grarup">Niels Grarup</name><affiliation wicri:level="3"><nlm:affiliation>Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Pedersen, Oluf" sort="Pedersen, Oluf" uniqKey="Pedersen O" first="Oluf" last="Pedersen">Oluf Pedersen</name><affiliation wicri:level="3"><nlm:affiliation>Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Hansen, Torben" sort="Hansen, Torben" uniqKey="Hansen T" first="Torben" last="Hansen">Torben Hansen</name><affiliation wicri:level="3"><nlm:affiliation>Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Linneberg, Allan" sort="Linneberg, Allan" uniqKey="Linneberg A" first="Allan" last="Linneberg">Allan Linneberg</name><affiliation wicri:level="3"><nlm:affiliation>Research Centre for Prevention and Health, Capital Region of Denmark, Denmark; Department of Clinical Experimental Research, Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Research Centre for Prevention and Health, Capital Region of Denmark, Denmark; Department of Clinical Experimental Research, Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Simonsen, Kenneth Starup" sort="Simonsen, Kenneth Starup" uniqKey="Simonsen K" first="Kenneth Starup" last="Simonsen">Kenneth Starup Simonsen</name><affiliation wicri:level="1"><nlm:affiliation>Research Centre for Prevention and Health, Capital Region of Denmark, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Research Centre for Prevention and Health, Capital Region of Denmark</wicri:regionArea><wicri:noRegion>Capital Region of Denmark</wicri:noRegion></affiliation></author><author><name sortKey="Cooper, Jackie" sort="Cooper, Jackie" uniqKey="Cooper J" first="Jackie" last="Cooper">Jackie Cooper</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Cardiovascular Genetics, University College London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cardiovascular Genetics, University College London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Humphries, Steve E" sort="Humphries, Steve E" uniqKey="Humphries S" first="Steve E" last="Humphries">Steve E. Humphries</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Cardiovascular Genetics, University College London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cardiovascular Genetics, University College London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Brilliant, Murray" sort="Brilliant, Murray" uniqKey="Brilliant M" first="Murray" last="Brilliant">Murray Brilliant</name><affiliation wicri:level="2"><nlm:affiliation>Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, WI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, WI</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Kitchner, Terrie" sort="Kitchner, Terrie" uniqKey="Kitchner T" first="Terrie" last="Kitchner">Terrie Kitchner</name><affiliation wicri:level="2"><nlm:affiliation>Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, WI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, WI</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name><affiliation wicri:level="2"><nlm:affiliation>Children's Hospital of Philadelphia, Philadelphia, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Children's Hospital of Philadelphia, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Carrell, David S" sort="Carrell, David S" uniqKey="Carrell D" first="David S" last="Carrell">David S. Carrell</name><affiliation wicri:level="2"><nlm:affiliation>Group Health Research Institute in Seattle, WA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Group Health Research Institute in Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Mccarty, Catherine A" sort="Mccarty, Catherine A" uniqKey="Mccarty C" first="Catherine A" last="Mccarty">Catherine A. Mccarty</name><affiliation wicri:level="2"><nlm:affiliation>Essentia Institute of Rural Health, Duluth, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Essentia Institute of Rural Health, Duluth, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Kirchner, H Lester" sort="Kirchner, H Lester" uniqKey="Kirchner H" first="H Lester" last="Kirchner">H Lester Kirchner</name><affiliation wicri:level="2"><nlm:affiliation>Center for Health Research, Geisinger Clinic, Danville, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Health Research, Geisinger Clinic, Danville, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Larson, Eric B" sort="Larson, Eric B" uniqKey="Larson E" first="Eric B" last="Larson">Eric B. Larson</name><affiliation wicri:level="2"><nlm:affiliation>Group Health Research Institute, Seattle, WA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Group Health Research Institute, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Crosslin, David R" sort="Crosslin, David R" uniqKey="Crosslin D" first="David R" last="Crosslin">David R. Crosslin</name><affiliation wicri:level="2"><nlm:affiliation>Group Health Research Institute, Seattle, WA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Group Health Research Institute, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="De Andrade, Mariza" sort="De Andrade, Mariza" uniqKey="De Andrade M" first="Mariza" last="De Andrade">Mariza De Andrade</name><affiliation wicri:level="2"><nlm:affiliation>Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Roden, Dan M" sort="Roden, Dan M" uniqKey="Roden D" first="Dan M" last="Roden">Dan M. Roden</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Denny, Joshua C" sort="Denny, Joshua C" uniqKey="Denny J" first="Joshua C" last="Denny">Joshua C. Denny</name><affiliation wicri:level="2"><nlm:affiliation>Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Carty, Cara" sort="Carty, Cara" uniqKey="Carty C" first="Cara" last="Carty">Cara Carty</name><affiliation wicri:level="2"><nlm:affiliation>George Washington University, Washington, DC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>George Washington University, Washington, DC</wicri:regionArea><placeName><region type="state">District de Columbia</region></placeName></affiliation></author><author><name sortKey="Hancock, Stephen" sort="Hancock, Stephen" uniqKey="Hancock S" first="Stephen" last="Hancock">Stephen Hancock</name><affiliation wicri:level="1"><nlm:affiliation>University of Newcastle, Newcastle, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>University of Newcastle, Newcastle, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Attia, John" sort="Attia, John" uniqKey="Attia J" first="John" last="Attia">John Attia</name><affiliation wicri:level="1"><nlm:affiliation>University of Newcastle, Newcastle, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>University of Newcastle, Newcastle, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Holliday, Elizabeth" sort="Holliday, Elizabeth" uniqKey="Holliday E" first="Elizabeth" last="Holliday">Elizabeth Holliday</name><affiliation wicri:level="1"><nlm:affiliation>University of Newcastle, Newcastle, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>University of Newcastle, Newcastle, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="O Donnell, Martin" sort="O Donnell, Martin" uniqKey="O Donnell M" first="Martin" last="O'Donnell">Martin O'Donnell</name><affiliation wicri:level="1"><nlm:affiliation>Population Health Research Institute, Hamilton, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Population Health Research Institute, Hamilton, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Yusuf, Salim" sort="Yusuf, Salim" uniqKey="Yusuf S" first="Salim" last="Yusuf">Salim Yusuf</name><affiliation wicri:level="1"><nlm:affiliation>Population Health Research Institute, Hamilton, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Population Health Research Institute, Hamilton, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Chong, Michael" sort="Chong, Michael" uniqKey="Chong M" first="Michael" last="Chong">Michael Chong</name><affiliation wicri:level="1"><nlm:affiliation>Population Health Research Institute, Hamilton, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Population Health Research Institute, Hamilton, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Pare, Guillaume" sort="Pare, Guillaume" uniqKey="Pare G" first="Guillaume" last="Pare">Guillaume Pare</name><affiliation wicri:level="1"><nlm:affiliation>Population Health Research Institute, Hamilton, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Population Health Research Institute, Hamilton, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name><affiliation wicri:level="3"><nlm:affiliation>Durrer Center for Cardiovascular Research, Netherlands Heart Institute, Utrecht, Netherlands; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Durrer Center for Cardiovascular Research, Netherlands Heart Institute, Utrecht, Netherlands; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Said, M Abdullah" sort="Said, M Abdullah" uniqKey="Said M" first="M Abdullah" last="Said">M Abdullah Said</name><affiliation wicri:level="3"><nlm:affiliation>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Eppinga, Ruben N" sort="Eppinga, Ruben N" uniqKey="Eppinga R" first="Ruben N" last="Eppinga">Ruben N. Eppinga</name><affiliation wicri:level="3"><nlm:affiliation>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Verweij, Niek" sort="Verweij, Niek" uniqKey="Verweij N" first="Niek" last="Verweij">Niek Verweij</name><affiliation wicri:level="3"><nlm:affiliation>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Snieder, Harold" sort="Snieder, Harold" uniqKey="Snieder H" first="Harold" last="Snieder">Harold Snieder</name><affiliation wicri:level="3"><nlm:affiliation>Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Christen, Tim" sort="Christen, Tim" uniqKey="Christen T" first="Tim" last="Christen">Tim Christen</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Epidemiology, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Mook Kanamori, Dennis O" sort="Mook Kanamori, Dennis O" uniqKey="Mook Kanamori D" first="Dennis O" last="Mook-Kanamori">Dennis O. Mook-Kanamori</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Epidemiology, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Gustafsson, Stefan" sort="Gustafsson, Stefan" uniqKey="Gustafsson S" first="Stefan" last="Gustafsson">Stefan Gustafsson</name><affiliation wicri:level="4"><nlm:affiliation>Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Lind, Lars" sort="Lind, Lars" uniqKey="Lind L" first="Lars" last="Lind">Lars Lind</name><affiliation wicri:level="4"><nlm:affiliation>Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Ingelsson, Erik" sort="Ingelsson, Erik" uniqKey="Ingelsson E" first="Erik" last="Ingelsson">Erik Ingelsson</name><affiliation wicri:level="4"><nlm:affiliation>Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden; Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden; Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Uppsala</settlement></placeName><orgName type="university">Université d'Uppsala</orgName></affiliation></author><author><name sortKey="Pazoki, Raha" sort="Pazoki, Raha" uniqKey="Pazoki R" first="Raha" last="Pazoki">Raha Pazoki</name><affiliation wicri:level="3"><nlm:affiliation>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Franco, Oscar" sort="Franco, Oscar" uniqKey="Franco O" first="Oscar" last="Franco">Oscar Franco</name><affiliation wicri:level="3"><nlm:affiliation>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="3"><nlm:affiliation>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Uitterlinden, Andre" sort="Uitterlinden, Andre" uniqKey="Uitterlinden A" first="Andre" last="Uitterlinden">Andre Uitterlinden</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Dehghan, Abbas" sort="Dehghan, Abbas" uniqKey="Dehghan A" first="Abbas" last="Dehghan">Abbas Dehghan</name><affiliation wicri:level="3"><nlm:affiliation>Faculty of Medicine, and Department of Biostatistics and Epidemiology, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Faculty of Medicine, and Department of Biostatistics and Epidemiology, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK; Department of Epidemiology, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany; German Centre for Cardiovascular Research (DZHK), Greifswald, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany; German Centre for Cardiovascular Research (DZHK), Greifswald</wicri:regionArea><wicri:noRegion>Greifswald</wicri:noRegion><wicri:noRegion>Greifswald</wicri:noRegion><wicri:noRegion>Greifswald</wicri:noRegion></affiliation></author><author><name sortKey="Baumeister, Sebastian" sort="Baumeister, Sebastian" uniqKey="Baumeister S" first="Sebastian" last="Baumeister">Sebastian Baumeister</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany; Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany; Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg</wicri:regionArea><wicri:noRegion>Regensburg</wicri:noRegion><wicri:noRegion>Regensburg</wicri:noRegion><wicri:noRegion>Regensburg</wicri:noRegion></affiliation></author><author><name sortKey="Dorr, Marcus" sort="Dorr, Marcus" uniqKey="Dorr M" first="Marcus" last="Dörr">Marcus Dörr</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany; German Centre for Cardiovascular Research (DZHK), Greifswald, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany; German Centre for Cardiovascular Research (DZHK), Greifswald</wicri:regionArea><wicri:noRegion>Greifswald</wicri:noRegion><wicri:noRegion>Greifswald</wicri:noRegion><wicri:noRegion>Greifswald</wicri:noRegion></affiliation></author><author><name sortKey="Lerch, Markus M" sort="Lerch, Markus M" uniqKey="Lerch M" first="Markus M" last="Lerch">Markus M. Lerch</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine A, University Medicine Greifswald, Greifswald, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Medicine A, University Medicine Greifswald, Greifswald</wicri:regionArea><wicri:noRegion>Greifswald</wicri:noRegion><wicri:noRegion>Greifswald</wicri:noRegion><wicri:noRegion>Greifswald</wicri:noRegion></affiliation></author><author><name sortKey="Volker, Uwe" sort="Volker, Uwe" uniqKey="Volker U" first="Uwe" last="Völker">Uwe Völker</name><affiliation wicri:level="1"><nlm:affiliation>Interfaculty Institute of Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany; German Centre for Cardiovascular Research (DZHK), Greifswald, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Interfaculty Institute of Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany; German Centre for Cardiovascular Research (DZHK), Greifswald</wicri:regionArea><wicri:noRegion>Greifswald</wicri:noRegion><wicri:noRegion>Greifswald</wicri:noRegion><wicri:noRegion>Greifswald</wicri:noRegion></affiliation></author><author><name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany; German Centre for Cardiovascular Research (DZHK), Greifswald, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany; German Centre for Cardiovascular Research (DZHK), Greifswald</wicri:regionArea><wicri:noRegion>Greifswald</wicri:noRegion><wicri:noRegion>Greifswald</wicri:noRegion><wicri:noRegion>Greifswald</wicri:noRegion></affiliation></author><author><name sortKey="Ward, Joey" sort="Ward, Joey" uniqKey="Ward J" first="Joey" last="Ward">Joey Ward</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Health & Wellbeing, University of Glasgow, Glasgow, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Health & Wellbeing, University of Glasgow, Glasgow</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Pell, Jill P" sort="Pell, Jill P" uniqKey="Pell J" first="Jill P" last="Pell">Jill P. Pell</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Health & Wellbeing, University of Glasgow, Glasgow, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Health & Wellbeing, University of Glasgow, Glasgow</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Smith, Daniel J" sort="Smith, Daniel J" uniqKey="Smith D" first="Daniel J" last="Smith">Daniel J. Smith</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Health & Wellbeing, University of Glasgow, Glasgow, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Health & Wellbeing, University of Glasgow, Glasgow</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Meade, Tom" sort="Meade, Tom" uniqKey="Meade T" first="Tom" last="Meade">Tom Meade</name><affiliation wicri:level="3"><nlm:affiliation>Department of Non-Communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Non-Communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Maitland Van Der Zee, Anke H" sort="Maitland Van Der Zee, Anke H" uniqKey="Maitland Van Der Zee A" first="Anke H" last="Maitland-Van Der Zee">Anke H. Maitland-Van Der Zee</name><affiliation wicri:level="4"><nlm:affiliation>Department of Respiratory Medicine, Academic Medical Center Amsterdam, Netherlands; Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Respiratory Medicine, Academic Medical Center Amsterdam, Netherlands; Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region><settlement type="city">Utrecht</settlement></placeName><orgName type="university">Université d'Utrecht</orgName></affiliation></author><author><name sortKey="Baranova, Ekaterina V" sort="Baranova, Ekaterina V" uniqKey="Baranova E" first="Ekaterina V" last="Baranova">Ekaterina V. Baranova</name><affiliation wicri:level="4"><nlm:affiliation>Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region><settlement type="city">Utrecht</settlement></placeName><orgName type="university">Université d'Utrecht</orgName></affiliation></author><author><name sortKey="Young, Robin" sort="Young, Robin" uniqKey="Young R" first="Robin" last="Young">Robin Young</name><affiliation wicri:level="4"><nlm:affiliation>Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Robertson Centre for Biostatistics, University of Glasgow, Glasgow</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Ford, Ian" sort="Ford, Ian" uniqKey="Ford I" first="Ian" last="Ford">Ian Ford</name><affiliation wicri:level="4"><nlm:affiliation>Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Robertson Centre for Biostatistics, University of Glasgow, Glasgow</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Campbell, Archie" sort="Campbell, Archie" uniqKey="Campbell A" first="Archie" last="Campbell">Archie Campbell</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh</wicri:regionArea><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region><settlement type="city">Édimbourg</settlement></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Padmanabhan, Sandosh" sort="Padmanabhan, Sandosh" uniqKey="Padmanabhan S" first="Sandosh" last="Padmanabhan">Sandosh Padmanabhan</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Bots, Michiel L" sort="Bots, Michiel L" uniqKey="Bots M" first="Michiel L" last="Bots">Michiel L. Bots</name><affiliation wicri:level="3"><nlm:affiliation>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Grobbee, Diederick E" sort="Grobbee, Diederick E" uniqKey="Grobbee D" first="Diederick E" last="Grobbee">Diederick E. Grobbee</name><affiliation wicri:level="3"><nlm:affiliation>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><affiliation wicri:level="3"><nlm:affiliation>Department of Genomics of Common Disease, Imperial College London, London, UK; CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Genomics of Common Disease, Imperial College London, London, UK; CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Thuillier, Dorothee" sort="Thuillier, Dorothee" uniqKey="Thuillier D" first="Dorothée" last="Thuillier">Dorothée Thuillier</name><affiliation wicri:level="3"><nlm:affiliation>CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Balkau, Beverley" sort="Balkau, Beverley" uniqKey="Balkau B" first="Beverley" last="Balkau">Beverley Balkau</name><affiliation wicri:level="1"><nlm:affiliation>Renal and Cardiovascular Epidemiology, Centre de Recherche en Epidémiologie et Santé des Populations (CESP), INSERM U1018, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Renal and Cardiovascular Epidemiology, Centre de Recherche en Epidémiologie et Santé des Populations (CESP), INSERM U1018, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Bonnefond, Amelie" sort="Bonnefond, Amelie" uniqKey="Bonnefond A" first="Amélie" last="Bonnefond">Amélie Bonnefond</name><affiliation wicri:level="3"><nlm:affiliation>Department of Genomics of Common Disease, Imperial College London, London, UK; CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Genomics of Common Disease, Imperial College London, London, UK; CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Cariou, Bertrand" sort="Cariou, Bertrand" uniqKey="Cariou B" first="Bertrand" last="Cariou">Bertrand Cariou</name><affiliation wicri:level="3"><nlm:affiliation>I'institut du Thorax, INSERM, CNRS, University of Nantes, CHU de Nantes, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>I'institut du Thorax, INSERM, CNRS, University of Nantes, CHU de Nantes, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Smart, Melissa" sort="Smart, Melissa" uniqKey="Smart M" first="Melissa" last="Smart">Melissa Smart</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Social and Economic Research, University of Essex, Colchester, Essex, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute for Social and Economic Research, University of Essex, Colchester, Essex</wicri:regionArea><wicri:noRegion>Essex</wicri:noRegion></affiliation></author><author><name sortKey="Bao, Yanchun" sort="Bao, Yanchun" uniqKey="Bao Y" first="Yanchun" last="Bao">Yanchun Bao</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Social and Economic Research, University of Essex, Colchester, Essex, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute for Social and Economic Research, University of Essex, Colchester, Essex</wicri:regionArea><wicri:noRegion>Essex</wicri:noRegion></affiliation></author><author><name sortKey="Kumari, Meena" sort="Kumari, Meena" uniqKey="Kumari M" first="Meena" last="Kumari">Meena Kumari</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Social and Economic Research, University of Essex, Colchester, Essex, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute for Social and Economic Research, University of Essex, Colchester, Essex</wicri:regionArea><wicri:noRegion>Essex</wicri:noRegion></affiliation></author><author><name sortKey="Mahajan, Anubha" sort="Mahajan, Anubha" uniqKey="Mahajan A" first="Anubha" last="Mahajan">Anubha Mahajan</name><affiliation wicri:level="4"><nlm:affiliation>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M" last="Ridker">Paul M. Ridker</name><affiliation wicri:level="2"><nlm:affiliation>Harvard Medical School Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard Medical School Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I" last="Chasman">Daniel I. Chasman</name><affiliation wicri:level="2"><nlm:affiliation>Harvard Medical School Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard Medical School Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Reiner, Alex P" sort="Reiner, Alex P" uniqKey="Reiner A" first="Alex P" last="Reiner">Alex P. Reiner</name><affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Lange, Leslie A" sort="Lange, Leslie A" uniqKey="Lange L" first="Leslie A" last="Lange">Leslie A. Lange</name><affiliation wicri:level="2"><nlm:affiliation>Anschutz Medical Campus, University of Colorado Denver, Denver, CO, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Anschutz Medical Campus, University of Colorado Denver, Denver, CO</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Ritchie, Marylyn D" sort="Ritchie, Marylyn D" uniqKey="Ritchie M" first="Marylyn D" last="Ritchie">Marylyn D. Ritchie</name><affiliation wicri:level="4"><nlm:affiliation>Biomedical and Translational Informatics, Geisinger Health System, Danville, PA, USA; Department of Biochemistry and Molecular Biology, Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biomedical and Translational Informatics, Geisinger Health System, Danville, PA, USA; Department of Biochemistry and Molecular Biology, Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">University Park (Pennsylvanie)</settlement></placeName><orgName type="university">Université d'État de Pennsylvanie</orgName></affiliation></author><author><name sortKey="Asselbergs, Folkert W" sort="Asselbergs, Folkert W" uniqKey="Asselbergs F" first="Folkert W" last="Asselbergs">Folkert W. Asselbergs</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Cardiovascular Science, University College London, UK; Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London, UK; Durrer Center for Cardiovascular Research, Netherlands Heart Institute, Utrecht, Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands; Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Institute of Cardiovascular Science, University College London, UK; Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London, UK; Durrer Center for Cardiovascular Research, Netherlands Heart Institute, Utrecht, Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands; Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Casas, Juan Pablo" sort="Casas, Juan Pablo" uniqKey="Casas J" first="Juan-Pablo" last="Casas">Juan-Pablo Casas</name><affiliation wicri:level="4"><nlm:affiliation>Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Keating, Brendan J" sort="Keating, Brendan J" uniqKey="Keating B" first="Brendan J" last="Keating">Brendan J. Keating</name><affiliation wicri:level="2"><nlm:affiliation>Department of Surgery, University of Pennsylvania, Philadelphia, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Surgery, University of Pennsylvania, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Preiss, David" sort="Preiss, David" uniqKey="Preiss D" first="David" last="Preiss">David Preiss</name><affiliation wicri:level="4"><nlm:affiliation>Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK; Medical Research Council Population Health Research Unit at the University of Oxford, University of Oxford, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK; Medical Research Council Population Health Research Unit at the University of Oxford, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Hingorani, Aroon D" sort="Hingorani, Aroon D" uniqKey="Hingorani A" first="Aroon D" last="Hingorani">Aroon D. Hingorani</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Cardiovascular Science, University College London, UK; Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cardiovascular Science, University College London, UK; Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Sattar, Naveed" sort="Sattar, Naveed" uniqKey="Sattar N" first="Naveed" last="Sattar">Naveed Sattar</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK. Electronic address: naveed.sattar@glasgow.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:27908689</idno><idno type="pmid">27908689</idno><idno type="doi">10.1016/S2213-8587(16)30396-5</idno><idno type="wicri:Area/PubMed/Corpus">001162</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001162</idno><idno type="wicri:Area/PubMed/Curation">001159</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001159</idno><idno type="wicri:Area/PubMed/Checkpoint">001159</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001159</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study.</title><author><name sortKey="Schmidt, Amand F" sort="Schmidt, Amand F" uniqKey="Schmidt A" first="Amand F" last="Schmidt">Amand F. Schmidt</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Cardiovascular Science, University College London, UK; Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London, UK. Electronic address: amand.schmidt@ucl.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cardiovascular Science, University College London, UK; Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Swerdlow, Daniel I" sort="Swerdlow, Daniel I" uniqKey="Swerdlow D" first="Daniel I" last="Swerdlow">Daniel I. Swerdlow</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Cardiovascular Science, University College London, UK; Department of Medicine, Imperial College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cardiovascular Science, University College London, UK; Department of Medicine, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Holmes, Michael V" sort="Holmes, Michael V" uniqKey="Holmes M" first="Michael V" last="Holmes">Michael V. Holmes</name><affiliation wicri:level="4"><nlm:affiliation>Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK; Medical Research Council Population Health Research Unit at the University of Oxford, University of Oxford, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK; Medical Research Council Population Health Research Unit at the University of Oxford, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Patel, Riyaz S" sort="Patel, Riyaz S" uniqKey="Patel R" first="Riyaz S" last="Patel">Riyaz S. Patel</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Cardiovascular Science, University College London, UK; Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London, UK; The Barts Heart Centre, St Bartholomew's Hospital, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cardiovascular Science, University College London, UK; Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London, UK; The Barts Heart Centre, St Bartholomew's Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Fairhurst Hunter, Zammy" sort="Fairhurst Hunter, Zammy" uniqKey="Fairhurst Hunter Z" first="Zammy" last="Fairhurst-Hunter">Zammy Fairhurst-Hunter</name><affiliation wicri:level="4"><nlm:affiliation>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Lyall, Donald M" sort="Lyall, Donald M" uniqKey="Lyall D" first="Donald M" last="Lyall">Donald M. Lyall</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Health & Wellbeing, University of Glasgow, Glasgow, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Health & Wellbeing, University of Glasgow, Glasgow</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Hartwig, Fernando Pires" sort="Hartwig, Fernando Pires" uniqKey="Hartwig F" first="Fernando Pires" last="Hartwig">Fernando Pires Hartwig</name><affiliation wicri:level="1"><nlm:affiliation>Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas</wicri:regionArea><wicri:noRegion>Pelotas</wicri:noRegion></affiliation></author><author><name sortKey="Horta, Bernardo Lessa" sort="Horta, Bernardo Lessa" uniqKey="Horta B" first="Bernardo Lessa" last="Horta">Bernardo Lessa Horta</name><affiliation wicri:level="1"><nlm:affiliation>Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas</wicri:regionArea><wicri:noRegion>Pelotas</wicri:noRegion></affiliation></author><author><name sortKey="Hypponen, Elina" sort="Hypponen, Elina" uniqKey="Hypponen E" first="Elina" last="Hyppönen">Elina Hyppönen</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Population Health Research, Sansom Institute for Health Research, University of South Australia, Adelaide, SA, Australia; Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London, UK; South Australian Health and Medical Research Institute, Adelaide, SA, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Population Health Research, Sansom Institute for Health Research, University of South Australia, Adelaide, SA, Australia; Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London, UK; South Australian Health and Medical Research Institute, Adelaide, SA</wicri:regionArea><wicri:noRegion>SA</wicri:noRegion></affiliation></author><author><name sortKey="Power, Christine" sort="Power, Christine" uniqKey="Power C" first="Christine" last="Power">Christine Power</name><affiliation wicri:level="3"><nlm:affiliation>Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Moldovan, Max" sort="Moldovan, Max" uniqKey="Moldovan M" first="Max" last="Moldovan">Max Moldovan</name><affiliation wicri:level="1"><nlm:affiliation>School of Health Sciences, University of South Australia, Adelaide, SA, Australia; South Australian Health and Medical Research Institute-EMBL Australia, Adelaide, SA, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Health Sciences, University of South Australia, Adelaide, SA, Australia; South Australian Health and Medical Research Institute-EMBL Australia, Adelaide, SA</wicri:regionArea><wicri:noRegion>SA</wicri:noRegion></affiliation></author><author><name sortKey="Van Iperen, Erik" sort="Van Iperen, Erik" uniqKey="Van Iperen E" first="Erik" last="Van Iperen">Erik Van Iperen</name><affiliation wicri:level="1"><nlm:affiliation>Durrer Center for Cardiovascular Research, Netherlands Heart Institute, Utrecht, Netherlands; Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center Amsterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Durrer Center for Cardiovascular Research, Netherlands Heart Institute, Utrecht, Netherlands; Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center Amsterdam</wicri:regionArea><wicri:noRegion>Academic Medical Center Amsterdam</wicri:noRegion></affiliation></author><author><name sortKey="Hovingh, G Kees" sort="Hovingh, G Kees" uniqKey="Hovingh G" first="G Kees" last="Hovingh">G Kees Hovingh</name><affiliation wicri:level="1"><nlm:affiliation>Department of Vascular Medicine, Academic Medical Center Amsterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Vascular Medicine, Academic Medical Center Amsterdam</wicri:regionArea><wicri:noRegion>Academic Medical Center Amsterdam</wicri:noRegion></affiliation></author><author><name sortKey="Demuth, Ilja" sort="Demuth, Ilja" uniqKey="Demuth I" first="Ilja" last="Demuth">Ilja Demuth</name><affiliation wicri:level="3"><nlm:affiliation>Charité Research Group on Geriatrics, Charité-Universitätsmedizin Berlin, Berlin, Germany; Institute of Medical and Human Genetics, Charité-Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Charité Research Group on Geriatrics, Charité-Universitätsmedizin Berlin, Berlin, Germany; Institute of Medical and Human Genetics, Charité-Universitätsmedizin Berlin, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Norman, Kristina" sort="Norman, Kristina" uniqKey="Norman K" first="Kristina" last="Norman">Kristina Norman</name><affiliation wicri:level="3"><nlm:affiliation>Charité Research Group on Geriatrics, Charité-Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Charité Research Group on Geriatrics, Charité-Universitätsmedizin Berlin, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Steinhagen Thiessen, Elisabeth" sort="Steinhagen Thiessen, Elisabeth" uniqKey="Steinhagen Thiessen E" first="Elisabeth" last="Steinhagen-Thiessen">Elisabeth Steinhagen-Thiessen</name><affiliation wicri:level="3"><nlm:affiliation>Charité Research Group on Geriatrics, Charité-Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Charité Research Group on Geriatrics, Charité-Universitätsmedizin Berlin, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Demuth, Juri" sort="Demuth, Juri" uniqKey="Demuth J" first="Juri" last="Demuth">Juri Demuth</name><affiliation wicri:level="3"><nlm:affiliation>E.CA Economics GmbH, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>E.CA Economics GmbH, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Bertram, Lars" sort="Bertram, Lars" uniqKey="Bertram L" first="Lars" last="Bertram">Lars Bertram</name><affiliation wicri:level="1"><nlm:affiliation>Neuroepidemiology and Ageing Research Unit, Imperial College London, London, UK; Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), Institutes of Neurogenetics and Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Neuroepidemiology and Ageing Research Unit, Imperial College London, London, UK; Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), Institutes of Neurogenetics and Integrative and Experimental Genomics, University of Lübeck, Lübeck</wicri:regionArea><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Tian" sort="Liu, Tian" uniqKey="Liu T" first="Tian" last="Liu">Tian Liu</name><affiliation wicri:level="3"><nlm:affiliation>Max Planck Institute for Human Development, Berlin, Germany; Max Planck Institute for Molecular Genetics, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max Planck Institute for Human Development, Berlin, Germany; Max Planck Institute for Molecular Genetics, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Coassin, Stefan" sort="Coassin, Stefan" uniqKey="Coassin S" first="Stefan" last="Coassin">Stefan Coassin</name><affiliation wicri:level="4"><nlm:affiliation>Division of Genetic Epidemiology Innsbruck, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Division of Genetic Epidemiology Innsbruck, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck</wicri:regionArea><orgName type="university">Université de médecine d'Innsbruck</orgName><placeName><settlement type="city">Innsbruck</settlement><region nuts="2" type="region">Tyrol (Land)</region></placeName></affiliation></author><author><name sortKey="Willeit, Johann" sort="Willeit, Johann" uniqKey="Willeit J" first="Johann" last="Willeit">Johann Willeit</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University of Innsbruck, Innsbruck</wicri:regionArea><orgName type="university">Université de médecine d'Innsbruck</orgName><placeName><settlement type="city">Innsbruck</settlement><region nuts="2" type="region">Tyrol (Land)</region></placeName></affiliation></author><author><name sortKey="Kiechl, Stefan" sort="Kiechl, Stefan" uniqKey="Kiechl S" first="Stefan" last="Kiechl">Stefan Kiechl</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University of Innsbruck, Innsbruck</wicri:regionArea><orgName type="university">Université de médecine d'Innsbruck</orgName><placeName><settlement type="city">Innsbruck</settlement><region nuts="2" type="region">Tyrol (Land)</region></placeName></affiliation></author><author><name sortKey="Willeit, Karin" sort="Willeit, Karin" uniqKey="Willeit K" first="Karin" last="Willeit">Karin Willeit</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University of Innsbruck, Innsbruck</wicri:regionArea><orgName type="university">Université de médecine d'Innsbruck</orgName><placeName><settlement type="city">Innsbruck</settlement><region nuts="2" type="region">Tyrol (Land)</region></placeName></affiliation></author><author><name sortKey="Mason, Dan" sort="Mason, Dan" uniqKey="Mason D" first="Dan" last="Mason">Dan Mason</name><affiliation wicri:level="1"><nlm:affiliation>Bradford Institute for Health Research, Bradford Royal Infirmary, Bradford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Bradford Institute for Health Research, Bradford Royal Infirmary, Bradford</wicri:regionArea><wicri:noRegion>Bradford</wicri:noRegion></affiliation></author><author><name sortKey="Wright, John" sort="Wright, John" uniqKey="Wright J" first="John" last="Wright">John Wright</name><affiliation wicri:level="1"><nlm:affiliation>Bradford Institute for Health Research, Bradford Royal Infirmary, Bradford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Bradford Institute for Health Research, Bradford Royal Infirmary, Bradford</wicri:regionArea><wicri:noRegion>Bradford</wicri:noRegion></affiliation></author><author><name sortKey="Morris, Richard" sort="Morris, Richard" uniqKey="Morris R" first="Richard" last="Morris">Richard Morris</name><affiliation wicri:level="1"><nlm:affiliation>School of Social and Community Medicine, University of Bristol, Bristol, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Wanamethee, Goya" sort="Wanamethee, Goya" uniqKey="Wanamethee G" first="Goya" last="Wanamethee">Goya Wanamethee</name><affiliation wicri:level="4"><nlm:affiliation>Department of Primary Care & Population Health, University College London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Primary Care & Population Health, University College London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Whincup, Peter" sort="Whincup, Peter" uniqKey="Whincup P" first="Peter" last="Whincup">Peter Whincup</name><affiliation wicri:level="4"><nlm:affiliation>Population Health Research Institute, St George's, University of London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Population Health Research Institute, St George's, University of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Ben Shlomo, Yoav" sort="Ben Shlomo, Yoav" uniqKey="Ben Shlomo Y" first="Yoav" last="Ben-Shlomo">Yoav Ben-Shlomo</name><affiliation wicri:level="1"><nlm:affiliation>School of Social and Community Medicine, University of Bristol, Bristol, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Mclachlan, Stela" sort="Mclachlan, Stela" uniqKey="Mclachlan S" first="Stela" last="Mclachlan">Stela Mclachlan</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh</wicri:regionArea><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region><settlement type="city">Édimbourg</settlement></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Price, Jackie F" sort="Price, Jackie F" uniqKey="Price J" first="Jackie F" last="Price">Jackie F. Price</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh</wicri:regionArea><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region><settlement type="city">Édimbourg</settlement></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Kivimaki, Mika" sort="Kivimaki, Mika" uniqKey="Kivimaki M" first="Mika" last="Kivimaki">Mika Kivimaki</name><affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Welch, Catherine" sort="Welch, Catherine" uniqKey="Welch C" first="Catherine" last="Welch">Catherine Welch</name><affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Sanchez Galvez, Adelaida" sort="Sanchez Galvez, Adelaida" uniqKey="Sanchez Galvez A" first="Adelaida" last="Sanchez-Galvez">Adelaida Sanchez-Galvez</name><affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Marques Vidal, Pedro" sort="Marques Vidal, Pedro" uniqKey="Marques Vidal P" first="Pedro" last="Marques-Vidal">Pedro Marques-Vidal</name><affiliation wicri:level="3"><nlm:affiliation>Internal Medicine Unit, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Internal Medicine Unit, Department of Medicine, Lausanne University Hospital, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Nicolaides, Andrew" sort="Nicolaides, Andrew" uniqKey="Nicolaides A" first="Andrew" last="Nicolaides">Andrew Nicolaides</name><affiliation wicri:level="1"><nlm:affiliation>Department of Vascular Surgery, Imperial College London, London, UK; Department of Surgery, Nicosia Medical School, University of Nicosia, Nicosia, Cyprus.</nlm:affiliation><country xml:lang="fr">Chypre (pays)</country><wicri:regionArea>Department of Vascular Surgery, Imperial College London, London, UK; Department of Surgery, Nicosia Medical School, University of Nicosia, Nicosia</wicri:regionArea><wicri:noRegion>Nicosia</wicri:noRegion></affiliation></author><author><name sortKey="Panayiotou, Andrie G" sort="Panayiotou, Andrie G" uniqKey="Panayiotou A" first="Andrie G" last="Panayiotou">Andrie G. Panayiotou</name><affiliation wicri:level="1"><nlm:affiliation>Cyprus International Institute for Environmental and Public Health, Cyprus University of Technology, Limassol, Cyprus.</nlm:affiliation><country xml:lang="fr">Chypre (pays)</country><wicri:regionArea>Cyprus International Institute for Environmental and Public Health, Cyprus University of Technology, Limassol</wicri:regionArea><wicri:noRegion>Limassol</wicri:noRegion></affiliation></author><author><name sortKey="Onland Moret, N Charlotte" sort="Onland Moret, N Charlotte" uniqKey="Onland Moret N" first="N Charlotte" last="Onland-Moret">N Charlotte Onland-Moret</name><affiliation wicri:level="3"><nlm:affiliation>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Van Der Schouw, Yvonne T" sort="Van Der Schouw, Yvonne T" uniqKey="Van Der Schouw Y" first="Yvonne T" last="Van Der Schouw">Yvonne T. Van Der Schouw</name><affiliation wicri:level="3"><nlm:affiliation>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Matullo, Giuseppe" sort="Matullo, Giuseppe" uniqKey="Matullo G" first="Giuseppe" last="Matullo">Giuseppe Matullo</name><affiliation wicri:level="3"><nlm:affiliation>Human Genetics Foundation, HuGeF, Turin, Italy; Department of Medical Sciences, University of Turin, Turin, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Human Genetics Foundation, HuGeF, Turin, Italy; Department of Medical Sciences, University of Turin, Turin</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Fiorito, Giovanni" sort="Fiorito, Giovanni" uniqKey="Fiorito G" first="Giovanni" last="Fiorito">Giovanni Fiorito</name><affiliation wicri:level="3"><nlm:affiliation>Human Genetics Foundation, HuGeF, Turin, Italy; Department of Medical Sciences, University of Turin, Turin, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Human Genetics Foundation, HuGeF, Turin, Italy; Department of Medical Sciences, University of Turin, Turin</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Guarrera, Simonetta" sort="Guarrera, Simonetta" uniqKey="Guarrera S" first="Simonetta" last="Guarrera">Simonetta Guarrera</name><affiliation wicri:level="3"><nlm:affiliation>Human Genetics Foundation, HuGeF, Turin, Italy; Department of Medical Sciences, University of Turin, Turin, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Human Genetics Foundation, HuGeF, Turin, Italy; Department of Medical Sciences, University of Turin, Turin</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Sacerdote, Carlotta" sort="Sacerdote, Carlotta" uniqKey="Sacerdote C" first="Carlotta" last="Sacerdote">Carlotta Sacerdote</name><affiliation wicri:level="3"><nlm:affiliation>Cancer Epidemiology Unit, San Giovanni Battista Hospital, Turin, Italy; Centre for Oncology Prevention, CPO Piemonte, Turin, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Cancer Epidemiology Unit, San Giovanni Battista Hospital, Turin, Italy; Centre for Oncology Prevention, CPO Piemonte, Turin</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J" last="Wareham">Nicholas J. Wareham</name><affiliation wicri:level="1"><nlm:affiliation>MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Langenberg, Claudia" sort="Langenberg, Claudia" uniqKey="Langenberg C" first="Claudia" last="Langenberg">Claudia Langenberg</name><affiliation wicri:level="1"><nlm:affiliation>MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Scott, Robert" sort="Scott, Robert" uniqKey="Scott R" first="Robert" last="Scott">Robert Scott</name><affiliation wicri:level="1"><nlm:affiliation>MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Luan, Jian An" sort="Luan, Jian An" uniqKey="Luan J" first="Jian'An" last="Luan">Jian'An Luan</name><affiliation wicri:level="1"><nlm:affiliation>MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Bobak, Martin" sort="Bobak, Martin" uniqKey="Bobak M" first="Martin" last="Bobak">Martin Bobak</name><affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Malyutina, Sofia" sort="Malyutina, Sofia" uniqKey="Malyutina S" first="Sofia" last="Malyutina">Sofia Malyutina</name><affiliation wicri:level="1"><nlm:affiliation>Novosibirsk State Medical University, Novosibirsk, Russia; Institute of Internal and Preventive Medicine, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Novosibirsk State Medical University, Novosibirsk, Russia; Institute of Internal and Preventive Medicine, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk</wicri:regionArea><wicri:noRegion>Novosibirsk</wicri:noRegion></affiliation></author><author><name sortKey="Paj K, Andrzej" sort="Paj K, Andrzej" uniqKey="Paj K A" first="Andrzej" last="Paj K">Andrzej Paj K</name><affiliation wicri:level="1"><nlm:affiliation>Jagiellonian University Collegium Medicum, Krakow, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Jagiellonian University Collegium Medicum, Krakow</wicri:regionArea><wicri:noRegion>Krakow</wicri:noRegion></affiliation></author><author><name sortKey="Kubinova, Ruzena" sort="Kubinova, Ruzena" uniqKey="Kubinova R" first="Ruzena" last="Kubinova">Ruzena Kubinova</name><affiliation wicri:level="3"><nlm:affiliation>National Institute of Public Health, Prague, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>National Institute of Public Health, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Tamosiunas, Abdonas" sort="Tamosiunas, Abdonas" uniqKey="Tamosiunas A" first="Abdonas" last="Tamosiunas">Abdonas Tamosiunas</name><affiliation wicri:level="1"><nlm:affiliation>Lithuanian University of Health Sciences, Kaunas, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Lithuanian University of Health Sciences, Kaunas</wicri:regionArea><wicri:noRegion>Kaunas</wicri:noRegion></affiliation></author><author><name sortKey="Pikhart, Hynek" sort="Pikhart, Hynek" uniqKey="Pikhart H" first="Hynek" last="Pikhart">Hynek Pikhart</name><affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Husemoen, Lise Lotte Nystrup" sort="Husemoen, Lise Lotte Nystrup" uniqKey="Husemoen L" first="Lise Lotte Nystrup" last="Husemoen">Lise Lotte Nystrup Husemoen</name><affiliation wicri:level="1"><nlm:affiliation>Research Centre for Prevention and Health, Capital Region of Denmark, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Research Centre for Prevention and Health, Capital Region of Denmark</wicri:regionArea><wicri:noRegion>Capital Region of Denmark</wicri:noRegion></affiliation></author><author><name sortKey="Grarup, Niels" sort="Grarup, Niels" uniqKey="Grarup N" first="Niels" last="Grarup">Niels Grarup</name><affiliation wicri:level="3"><nlm:affiliation>Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Pedersen, Oluf" sort="Pedersen, Oluf" uniqKey="Pedersen O" first="Oluf" last="Pedersen">Oluf Pedersen</name><affiliation wicri:level="3"><nlm:affiliation>Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Hansen, Torben" sort="Hansen, Torben" uniqKey="Hansen T" first="Torben" last="Hansen">Torben Hansen</name><affiliation wicri:level="3"><nlm:affiliation>Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Linneberg, Allan" sort="Linneberg, Allan" uniqKey="Linneberg A" first="Allan" last="Linneberg">Allan Linneberg</name><affiliation wicri:level="3"><nlm:affiliation>Research Centre for Prevention and Health, Capital Region of Denmark, Denmark; Department of Clinical Experimental Research, Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Research Centre for Prevention and Health, Capital Region of Denmark, Denmark; Department of Clinical Experimental Research, Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Simonsen, Kenneth Starup" sort="Simonsen, Kenneth Starup" uniqKey="Simonsen K" first="Kenneth Starup" last="Simonsen">Kenneth Starup Simonsen</name><affiliation wicri:level="1"><nlm:affiliation>Research Centre for Prevention and Health, Capital Region of Denmark, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Research Centre for Prevention and Health, Capital Region of Denmark</wicri:regionArea><wicri:noRegion>Capital Region of Denmark</wicri:noRegion></affiliation></author><author><name sortKey="Cooper, Jackie" sort="Cooper, Jackie" uniqKey="Cooper J" first="Jackie" last="Cooper">Jackie Cooper</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Cardiovascular Genetics, University College London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cardiovascular Genetics, University College London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Humphries, Steve E" sort="Humphries, Steve E" uniqKey="Humphries S" first="Steve E" last="Humphries">Steve E. Humphries</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Cardiovascular Genetics, University College London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cardiovascular Genetics, University College London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Brilliant, Murray" sort="Brilliant, Murray" uniqKey="Brilliant M" first="Murray" last="Brilliant">Murray Brilliant</name><affiliation wicri:level="2"><nlm:affiliation>Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, WI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, WI</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Kitchner, Terrie" sort="Kitchner, Terrie" uniqKey="Kitchner T" first="Terrie" last="Kitchner">Terrie Kitchner</name><affiliation wicri:level="2"><nlm:affiliation>Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, WI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, WI</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name><affiliation wicri:level="2"><nlm:affiliation>Children's Hospital of Philadelphia, Philadelphia, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Children's Hospital of Philadelphia, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Carrell, David S" sort="Carrell, David S" uniqKey="Carrell D" first="David S" last="Carrell">David S. Carrell</name><affiliation wicri:level="2"><nlm:affiliation>Group Health Research Institute in Seattle, WA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Group Health Research Institute in Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Mccarty, Catherine A" sort="Mccarty, Catherine A" uniqKey="Mccarty C" first="Catherine A" last="Mccarty">Catherine A. Mccarty</name><affiliation wicri:level="2"><nlm:affiliation>Essentia Institute of Rural Health, Duluth, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Essentia Institute of Rural Health, Duluth, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Kirchner, H Lester" sort="Kirchner, H Lester" uniqKey="Kirchner H" first="H Lester" last="Kirchner">H Lester Kirchner</name><affiliation wicri:level="2"><nlm:affiliation>Center for Health Research, Geisinger Clinic, Danville, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Health Research, Geisinger Clinic, Danville, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Larson, Eric B" sort="Larson, Eric B" uniqKey="Larson E" first="Eric B" last="Larson">Eric B. Larson</name><affiliation wicri:level="2"><nlm:affiliation>Group Health Research Institute, Seattle, WA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Group Health Research Institute, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Crosslin, David R" sort="Crosslin, David R" uniqKey="Crosslin D" first="David R" last="Crosslin">David R. Crosslin</name><affiliation wicri:level="2"><nlm:affiliation>Group Health Research Institute, Seattle, WA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Group Health Research Institute, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="De Andrade, Mariza" sort="De Andrade, Mariza" uniqKey="De Andrade M" first="Mariza" last="De Andrade">Mariza De Andrade</name><affiliation wicri:level="2"><nlm:affiliation>Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Roden, Dan M" sort="Roden, Dan M" uniqKey="Roden D" first="Dan M" last="Roden">Dan M. Roden</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Denny, Joshua C" sort="Denny, Joshua C" uniqKey="Denny J" first="Joshua C" last="Denny">Joshua C. Denny</name><affiliation wicri:level="2"><nlm:affiliation>Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Carty, Cara" sort="Carty, Cara" uniqKey="Carty C" first="Cara" last="Carty">Cara Carty</name><affiliation wicri:level="2"><nlm:affiliation>George Washington University, Washington, DC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>George Washington University, Washington, DC</wicri:regionArea><placeName><region type="state">District de Columbia</region></placeName></affiliation></author><author><name sortKey="Hancock, Stephen" sort="Hancock, Stephen" uniqKey="Hancock S" first="Stephen" last="Hancock">Stephen Hancock</name><affiliation wicri:level="1"><nlm:affiliation>University of Newcastle, Newcastle, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>University of Newcastle, Newcastle, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Attia, John" sort="Attia, John" uniqKey="Attia J" first="John" last="Attia">John Attia</name><affiliation wicri:level="1"><nlm:affiliation>University of Newcastle, Newcastle, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>University of Newcastle, Newcastle, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Holliday, Elizabeth" sort="Holliday, Elizabeth" uniqKey="Holliday E" first="Elizabeth" last="Holliday">Elizabeth Holliday</name><affiliation wicri:level="1"><nlm:affiliation>University of Newcastle, Newcastle, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>University of Newcastle, Newcastle, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="O Donnell, Martin" sort="O Donnell, Martin" uniqKey="O Donnell M" first="Martin" last="O'Donnell">Martin O'Donnell</name><affiliation wicri:level="1"><nlm:affiliation>Population Health Research Institute, Hamilton, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Population Health Research Institute, Hamilton, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Yusuf, Salim" sort="Yusuf, Salim" uniqKey="Yusuf S" first="Salim" last="Yusuf">Salim Yusuf</name><affiliation wicri:level="1"><nlm:affiliation>Population Health Research Institute, Hamilton, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Population Health Research Institute, Hamilton, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Chong, Michael" sort="Chong, Michael" uniqKey="Chong M" first="Michael" last="Chong">Michael Chong</name><affiliation wicri:level="1"><nlm:affiliation>Population Health Research Institute, Hamilton, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Population Health Research Institute, Hamilton, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Pare, Guillaume" sort="Pare, Guillaume" uniqKey="Pare G" first="Guillaume" last="Pare">Guillaume Pare</name><affiliation wicri:level="1"><nlm:affiliation>Population Health Research Institute, Hamilton, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Population Health Research Institute, Hamilton, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name><affiliation wicri:level="3"><nlm:affiliation>Durrer Center for Cardiovascular Research, Netherlands Heart Institute, Utrecht, Netherlands; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Durrer Center for Cardiovascular Research, Netherlands Heart Institute, Utrecht, Netherlands; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Said, M Abdullah" sort="Said, M Abdullah" uniqKey="Said M" first="M Abdullah" last="Said">M Abdullah Said</name><affiliation wicri:level="3"><nlm:affiliation>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Eppinga, Ruben N" sort="Eppinga, Ruben N" uniqKey="Eppinga R" first="Ruben N" last="Eppinga">Ruben N. Eppinga</name><affiliation wicri:level="3"><nlm:affiliation>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Verweij, Niek" sort="Verweij, Niek" uniqKey="Verweij N" first="Niek" last="Verweij">Niek Verweij</name><affiliation wicri:level="3"><nlm:affiliation>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Snieder, Harold" sort="Snieder, Harold" uniqKey="Snieder H" first="Harold" last="Snieder">Harold Snieder</name><affiliation wicri:level="3"><nlm:affiliation>Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Christen, Tim" sort="Christen, Tim" uniqKey="Christen T" first="Tim" last="Christen">Tim Christen</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Epidemiology, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Mook Kanamori, Dennis O" sort="Mook Kanamori, Dennis O" uniqKey="Mook Kanamori D" first="Dennis O" last="Mook-Kanamori">Dennis O. Mook-Kanamori</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Epidemiology, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Gustafsson, Stefan" sort="Gustafsson, Stefan" uniqKey="Gustafsson S" first="Stefan" last="Gustafsson">Stefan Gustafsson</name><affiliation wicri:level="4"><nlm:affiliation>Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Lind, Lars" sort="Lind, Lars" uniqKey="Lind L" first="Lars" last="Lind">Lars Lind</name><affiliation wicri:level="4"><nlm:affiliation>Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Ingelsson, Erik" sort="Ingelsson, Erik" uniqKey="Ingelsson E" first="Erik" last="Ingelsson">Erik Ingelsson</name><affiliation wicri:level="4"><nlm:affiliation>Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden; Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden; Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Uppsala</settlement></placeName><orgName type="university">Université d'Uppsala</orgName></affiliation></author><author><name sortKey="Pazoki, Raha" sort="Pazoki, Raha" uniqKey="Pazoki R" first="Raha" last="Pazoki">Raha Pazoki</name><affiliation wicri:level="3"><nlm:affiliation>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Franco, Oscar" sort="Franco, Oscar" uniqKey="Franco O" first="Oscar" last="Franco">Oscar Franco</name><affiliation wicri:level="3"><nlm:affiliation>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="3"><nlm:affiliation>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Uitterlinden, Andre" sort="Uitterlinden, Andre" uniqKey="Uitterlinden A" first="Andre" last="Uitterlinden">Andre Uitterlinden</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Dehghan, Abbas" sort="Dehghan, Abbas" uniqKey="Dehghan A" first="Abbas" last="Dehghan">Abbas Dehghan</name><affiliation wicri:level="3"><nlm:affiliation>Faculty of Medicine, and Department of Biostatistics and Epidemiology, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Faculty of Medicine, and Department of Biostatistics and Epidemiology, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK; Department of Epidemiology, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany; German Centre for Cardiovascular Research (DZHK), Greifswald, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany; German Centre for Cardiovascular Research (DZHK), Greifswald</wicri:regionArea><wicri:noRegion>Greifswald</wicri:noRegion><wicri:noRegion>Greifswald</wicri:noRegion><wicri:noRegion>Greifswald</wicri:noRegion></affiliation></author><author><name sortKey="Baumeister, Sebastian" sort="Baumeister, Sebastian" uniqKey="Baumeister S" first="Sebastian" last="Baumeister">Sebastian Baumeister</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany; Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany; Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg</wicri:regionArea><wicri:noRegion>Regensburg</wicri:noRegion><wicri:noRegion>Regensburg</wicri:noRegion><wicri:noRegion>Regensburg</wicri:noRegion></affiliation></author><author><name sortKey="Dorr, Marcus" sort="Dorr, Marcus" uniqKey="Dorr M" first="Marcus" last="Dörr">Marcus Dörr</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany; German Centre for Cardiovascular Research (DZHK), Greifswald, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany; German Centre for Cardiovascular Research (DZHK), Greifswald</wicri:regionArea><wicri:noRegion>Greifswald</wicri:noRegion><wicri:noRegion>Greifswald</wicri:noRegion><wicri:noRegion>Greifswald</wicri:noRegion></affiliation></author><author><name sortKey="Lerch, Markus M" sort="Lerch, Markus M" uniqKey="Lerch M" first="Markus M" last="Lerch">Markus M. Lerch</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine A, University Medicine Greifswald, Greifswald, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Medicine A, University Medicine Greifswald, Greifswald</wicri:regionArea><wicri:noRegion>Greifswald</wicri:noRegion><wicri:noRegion>Greifswald</wicri:noRegion><wicri:noRegion>Greifswald</wicri:noRegion></affiliation></author><author><name sortKey="Volker, Uwe" sort="Volker, Uwe" uniqKey="Volker U" first="Uwe" last="Völker">Uwe Völker</name><affiliation wicri:level="1"><nlm:affiliation>Interfaculty Institute of Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany; German Centre for Cardiovascular Research (DZHK), Greifswald, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Interfaculty Institute of Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany; German Centre for Cardiovascular Research (DZHK), Greifswald</wicri:regionArea><wicri:noRegion>Greifswald</wicri:noRegion><wicri:noRegion>Greifswald</wicri:noRegion><wicri:noRegion>Greifswald</wicri:noRegion></affiliation></author><author><name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany; German Centre for Cardiovascular Research (DZHK), Greifswald, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany; German Centre for Cardiovascular Research (DZHK), Greifswald</wicri:regionArea><wicri:noRegion>Greifswald</wicri:noRegion><wicri:noRegion>Greifswald</wicri:noRegion><wicri:noRegion>Greifswald</wicri:noRegion></affiliation></author><author><name sortKey="Ward, Joey" sort="Ward, Joey" uniqKey="Ward J" first="Joey" last="Ward">Joey Ward</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Health & Wellbeing, University of Glasgow, Glasgow, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Health & Wellbeing, University of Glasgow, Glasgow</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Pell, Jill P" sort="Pell, Jill P" uniqKey="Pell J" first="Jill P" last="Pell">Jill P. Pell</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Health & Wellbeing, University of Glasgow, Glasgow, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Health & Wellbeing, University of Glasgow, Glasgow</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Smith, Daniel J" sort="Smith, Daniel J" uniqKey="Smith D" first="Daniel J" last="Smith">Daniel J. Smith</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Health & Wellbeing, University of Glasgow, Glasgow, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Health & Wellbeing, University of Glasgow, Glasgow</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Meade, Tom" sort="Meade, Tom" uniqKey="Meade T" first="Tom" last="Meade">Tom Meade</name><affiliation wicri:level="3"><nlm:affiliation>Department of Non-Communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Non-Communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Maitland Van Der Zee, Anke H" sort="Maitland Van Der Zee, Anke H" uniqKey="Maitland Van Der Zee A" first="Anke H" last="Maitland-Van Der Zee">Anke H. Maitland-Van Der Zee</name><affiliation wicri:level="4"><nlm:affiliation>Department of Respiratory Medicine, Academic Medical Center Amsterdam, Netherlands; Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Respiratory Medicine, Academic Medical Center Amsterdam, Netherlands; Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region><settlement type="city">Utrecht</settlement></placeName><orgName type="university">Université d'Utrecht</orgName></affiliation></author><author><name sortKey="Baranova, Ekaterina V" sort="Baranova, Ekaterina V" uniqKey="Baranova E" first="Ekaterina V" last="Baranova">Ekaterina V. Baranova</name><affiliation wicri:level="4"><nlm:affiliation>Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region><settlement type="city">Utrecht</settlement></placeName><orgName type="university">Université d'Utrecht</orgName></affiliation></author><author><name sortKey="Young, Robin" sort="Young, Robin" uniqKey="Young R" first="Robin" last="Young">Robin Young</name><affiliation wicri:level="4"><nlm:affiliation>Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Robertson Centre for Biostatistics, University of Glasgow, Glasgow</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Ford, Ian" sort="Ford, Ian" uniqKey="Ford I" first="Ian" last="Ford">Ian Ford</name><affiliation wicri:level="4"><nlm:affiliation>Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Robertson Centre for Biostatistics, University of Glasgow, Glasgow</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Campbell, Archie" sort="Campbell, Archie" uniqKey="Campbell A" first="Archie" last="Campbell">Archie Campbell</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh</wicri:regionArea><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region><settlement type="city">Édimbourg</settlement></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Padmanabhan, Sandosh" sort="Padmanabhan, Sandosh" uniqKey="Padmanabhan S" first="Sandosh" last="Padmanabhan">Sandosh Padmanabhan</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Bots, Michiel L" sort="Bots, Michiel L" uniqKey="Bots M" first="Michiel L" last="Bots">Michiel L. Bots</name><affiliation wicri:level="3"><nlm:affiliation>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Grobbee, Diederick E" sort="Grobbee, Diederick E" uniqKey="Grobbee D" first="Diederick E" last="Grobbee">Diederick E. Grobbee</name><affiliation wicri:level="3"><nlm:affiliation>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><affiliation wicri:level="3"><nlm:affiliation>Department of Genomics of Common Disease, Imperial College London, London, UK; CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Genomics of Common Disease, Imperial College London, London, UK; CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Thuillier, Dorothee" sort="Thuillier, Dorothee" uniqKey="Thuillier D" first="Dorothée" last="Thuillier">Dorothée Thuillier</name><affiliation wicri:level="3"><nlm:affiliation>CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Balkau, Beverley" sort="Balkau, Beverley" uniqKey="Balkau B" first="Beverley" last="Balkau">Beverley Balkau</name><affiliation wicri:level="1"><nlm:affiliation>Renal and Cardiovascular Epidemiology, Centre de Recherche en Epidémiologie et Santé des Populations (CESP), INSERM U1018, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Renal and Cardiovascular Epidemiology, Centre de Recherche en Epidémiologie et Santé des Populations (CESP), INSERM U1018, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Bonnefond, Amelie" sort="Bonnefond, Amelie" uniqKey="Bonnefond A" first="Amélie" last="Bonnefond">Amélie Bonnefond</name><affiliation wicri:level="3"><nlm:affiliation>Department of Genomics of Common Disease, Imperial College London, London, UK; CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Genomics of Common Disease, Imperial College London, London, UK; CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Cariou, Bertrand" sort="Cariou, Bertrand" uniqKey="Cariou B" first="Bertrand" last="Cariou">Bertrand Cariou</name><affiliation wicri:level="3"><nlm:affiliation>I'institut du Thorax, INSERM, CNRS, University of Nantes, CHU de Nantes, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>I'institut du Thorax, INSERM, CNRS, University of Nantes, CHU de Nantes, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Smart, Melissa" sort="Smart, Melissa" uniqKey="Smart M" first="Melissa" last="Smart">Melissa Smart</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Social and Economic Research, University of Essex, Colchester, Essex, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute for Social and Economic Research, University of Essex, Colchester, Essex</wicri:regionArea><wicri:noRegion>Essex</wicri:noRegion></affiliation></author><author><name sortKey="Bao, Yanchun" sort="Bao, Yanchun" uniqKey="Bao Y" first="Yanchun" last="Bao">Yanchun Bao</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Social and Economic Research, University of Essex, Colchester, Essex, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute for Social and Economic Research, University of Essex, Colchester, Essex</wicri:regionArea><wicri:noRegion>Essex</wicri:noRegion></affiliation></author><author><name sortKey="Kumari, Meena" sort="Kumari, Meena" uniqKey="Kumari M" first="Meena" last="Kumari">Meena Kumari</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Social and Economic Research, University of Essex, Colchester, Essex, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute for Social and Economic Research, University of Essex, Colchester, Essex</wicri:regionArea><wicri:noRegion>Essex</wicri:noRegion></affiliation></author><author><name sortKey="Mahajan, Anubha" sort="Mahajan, Anubha" uniqKey="Mahajan A" first="Anubha" last="Mahajan">Anubha Mahajan</name><affiliation wicri:level="4"><nlm:affiliation>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M" last="Ridker">Paul M. Ridker</name><affiliation wicri:level="2"><nlm:affiliation>Harvard Medical School Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard Medical School Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I" last="Chasman">Daniel I. Chasman</name><affiliation wicri:level="2"><nlm:affiliation>Harvard Medical School Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard Medical School Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Reiner, Alex P" sort="Reiner, Alex P" uniqKey="Reiner A" first="Alex P" last="Reiner">Alex P. Reiner</name><affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Lange, Leslie A" sort="Lange, Leslie A" uniqKey="Lange L" first="Leslie A" last="Lange">Leslie A. Lange</name><affiliation wicri:level="2"><nlm:affiliation>Anschutz Medical Campus, University of Colorado Denver, Denver, CO, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Anschutz Medical Campus, University of Colorado Denver, Denver, CO</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Ritchie, Marylyn D" sort="Ritchie, Marylyn D" uniqKey="Ritchie M" first="Marylyn D" last="Ritchie">Marylyn D. Ritchie</name><affiliation wicri:level="4"><nlm:affiliation>Biomedical and Translational Informatics, Geisinger Health System, Danville, PA, USA; Department of Biochemistry and Molecular Biology, Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biomedical and Translational Informatics, Geisinger Health System, Danville, PA, USA; Department of Biochemistry and Molecular Biology, Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">University Park (Pennsylvanie)</settlement></placeName><orgName type="university">Université d'État de Pennsylvanie</orgName></affiliation></author><author><name sortKey="Asselbergs, Folkert W" sort="Asselbergs, Folkert W" uniqKey="Asselbergs F" first="Folkert W" last="Asselbergs">Folkert W. Asselbergs</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Cardiovascular Science, University College London, UK; Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London, UK; Durrer Center for Cardiovascular Research, Netherlands Heart Institute, Utrecht, Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands; Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Institute of Cardiovascular Science, University College London, UK; Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London, UK; Durrer Center for Cardiovascular Research, Netherlands Heart Institute, Utrecht, Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands; Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Casas, Juan Pablo" sort="Casas, Juan Pablo" uniqKey="Casas J" first="Juan-Pablo" last="Casas">Juan-Pablo Casas</name><affiliation wicri:level="4"><nlm:affiliation>Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Keating, Brendan J" sort="Keating, Brendan J" uniqKey="Keating B" first="Brendan J" last="Keating">Brendan J. Keating</name><affiliation wicri:level="2"><nlm:affiliation>Department of Surgery, University of Pennsylvania, Philadelphia, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Surgery, University of Pennsylvania, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Preiss, David" sort="Preiss, David" uniqKey="Preiss D" first="David" last="Preiss">David Preiss</name><affiliation wicri:level="4"><nlm:affiliation>Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK; Medical Research Council Population Health Research Unit at the University of Oxford, University of Oxford, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK; Medical Research Council Population Health Research Unit at the University of Oxford, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Hingorani, Aroon D" sort="Hingorani, Aroon D" uniqKey="Hingorani A" first="Aroon D" last="Hingorani">Aroon D. Hingorani</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Cardiovascular Science, University College London, UK; Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cardiovascular Science, University College London, UK; Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Sattar, Naveed" sort="Sattar, Naveed" uniqKey="Sattar N" first="Naveed" last="Sattar">Naveed Sattar</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK. Electronic address: naveed.sattar@glasgow.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author></analytic><series><title level="j">The lancet. Diabetes & endocrinology</title><idno type="eISSN">2213-8595</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Statin treatment and variants in the gene encoding HMG-CoA reductase are associated with reductions in both the concentration of LDL cholesterol and the risk of coronary heart disease, but also with modest hyperglycaemia, increased bodyweight, and modestly increased risk of type 2 diabetes, which in no way offsets their substantial benefits. We sought to investigate the associations of LDL cholesterol-lowering PCSK9 variants with type 2 diabetes and related biomarkers to gauge the likely effects of PCSK9 inhibitors on diabetes risk.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">27908689</PMID><DateCreated><Year>2016</Year><Month>12</Month><Day>02</Day></DateCreated><DateRevised><Year>2017</Year><Month>11</Month><Day>18</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2213-8595</ISSN><JournalIssue CitedMedium="Internet"><Volume>5</Volume><Issue>2</Issue><PubDate><Year>2017</Year><Month>Feb</Month></PubDate></JournalIssue><Title>The lancet. Diabetes & endocrinology</Title><ISOAbbreviation>Lancet Diabetes Endocrinol</ISOAbbreviation></Journal><ArticleTitle>PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study.</ArticleTitle><Pagination><MedlinePgn>97-105</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S2213-8587(16)30396-5</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/S2213-8587(16)30396-5</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Statin treatment and variants in the gene encoding HMG-CoA reductase are associated with reductions in both the concentration of LDL cholesterol and the risk of coronary heart disease, but also with modest hyperglycaemia, increased bodyweight, and modestly increased risk of type 2 diabetes, which in no way offsets their substantial benefits. We sought to investigate the associations of LDL cholesterol-lowering PCSK9 variants with type 2 diabetes and related biomarkers to gauge the likely effects of PCSK9 inhibitors on diabetes risk.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">In this mendelian randomisation study, we used data from cohort studies, randomised controlled trials, case control studies, and genetic consortia to estimate associations of PCSK9 genetic variants with LDL cholesterol, fasting blood glucose, HbA1c, fasting insulin, bodyweight, waist-to-hip ratio, BMI, and risk of type 2 diabetes, using a standardised analysis plan, meta-analyses, and weighted gene-centric scores.</AbstractText><AbstractText Label="FINDINGS" NlmCategory="RESULTS">Data were available for more than 550 000 individuals and 51 623 cases of type 2 diabetes. Combined analyses of four independent PCSK9 variants (rs11583680, rs11591147, rs2479409, and rs11206510) scaled to 1 mmol/L lower LDL cholesterol showed associations with increased fasting glucose (0·09 mmol/L, 95% CI 0·02 to 0·15), bodyweight (1·03 kg, 0·24 to 1·82), waist-to-hip ratio (0·006, 0·003 to 0·010), and an odds ratio for type diabetes of 1·29 (1·11 to 1·50). Based on the collected data, we did not identify associations with HbA1c (0·03%, -0·01 to 0·08), fasting insulin (0·00%, -0·06 to 0·07), and BMI (0·11 kg/m(2), -0·09 to 0·30).</AbstractText><AbstractText Label="INTERPRETATION" NlmCategory="CONCLUSIONS">PCSK9 variants associated with lower LDL cholesterol were also associated with circulating higher fasting glucose concentration, bodyweight, and waist-to-hip ratio, and an increased risk of type 2 diabetes. In trials of PCSK9 inhibitor drugs, investigators should carefully assess these safety outcomes and quantify the risks and benefits of PCSK9 inhibitor treatment, as was previously done for statins.</AbstractText><AbstractText Label="FUNDING" NlmCategory="BACKGROUND">British Heart Foundation, and University College London Hospitals NHS Foundation Trust (UCLH) National Institute for Health Research (NIHR) Biomedical Research Centre.</AbstractText><CopyrightInformation>Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license. Published by Elsevier Ltd.. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Schmidt</LastName><ForeName>Amand F</ForeName><Initials>AF</Initials><AffiliationInfo><Affiliation>Institute of Cardiovascular Science, University College London, UK; Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London, UK. Electronic address: amand.schmidt@ucl.ac.uk.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Swerdlow</LastName><ForeName>Daniel I</ForeName><Initials>DI</Initials><AffiliationInfo><Affiliation>Institute of Cardiovascular Science, University College London, UK; Department of Medicine, Imperial College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Holmes</LastName><ForeName>Michael V</ForeName><Initials>MV</Initials><AffiliationInfo><Affiliation>Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK; Medical Research Council Population Health Research Unit at the University of Oxford, University of Oxford, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Patel</LastName><ForeName>Riyaz S</ForeName><Initials>RS</Initials><AffiliationInfo><Affiliation>Institute of Cardiovascular Science, University College London, UK; Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London, UK; The Barts Heart Centre, St Bartholomew's Hospital, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fairhurst-Hunter</LastName><ForeName>Zammy</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lyall</LastName><ForeName>Donald M</ForeName><Initials>DM</Initials><AffiliationInfo><Affiliation>Institute of Health & Wellbeing, University of Glasgow, Glasgow, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hartwig</LastName><ForeName>Fernando Pires</ForeName><Initials>FP</Initials><AffiliationInfo><Affiliation>Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Horta</LastName><ForeName>Bernardo Lessa</ForeName><Initials>BL</Initials><AffiliationInfo><Affiliation>Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hyppönen</LastName><ForeName>Elina</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Centre for Population Health Research, Sansom Institute for Health Research, University of South Australia, Adelaide, SA, Australia; Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London, UK; South Australian Health and Medical Research Institute, Adelaide, SA, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Power</LastName><ForeName>Christine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moldovan</LastName><ForeName>Max</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>School of Health Sciences, University of South Australia, Adelaide, SA, Australia; South Australian Health and Medical Research Institute-EMBL Australia, Adelaide, SA, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van Iperen</LastName><ForeName>Erik</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Durrer Center for Cardiovascular Research, Netherlands Heart Institute, Utrecht, Netherlands; Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center Amsterdam, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hovingh</LastName><ForeName>G Kees</ForeName><Initials>GK</Initials><AffiliationInfo><Affiliation>Department of Vascular Medicine, Academic Medical Center Amsterdam, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Demuth</LastName><ForeName>Ilja</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Charité Research Group on Geriatrics, Charité-Universitätsmedizin Berlin, Berlin, Germany; Institute of Medical and Human Genetics, Charité-Universitätsmedizin Berlin, Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Norman</LastName><ForeName>Kristina</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Charité Research Group on Geriatrics, Charité-Universitätsmedizin Berlin, Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Steinhagen-Thiessen</LastName><ForeName>Elisabeth</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Charité Research Group on Geriatrics, Charité-Universitätsmedizin Berlin, Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Demuth</LastName><ForeName>Juri</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>E.CA Economics GmbH, Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bertram</LastName><ForeName>Lars</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Neuroepidemiology and Ageing Research Unit, Imperial College London, London, UK; Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), Institutes of Neurogenetics and Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Tian</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Max Planck Institute for Human Development, Berlin, Germany; Max Planck Institute for Molecular Genetics, Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Coassin</LastName><ForeName>Stefan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Division of Genetic Epidemiology Innsbruck, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Willeit</LastName><ForeName>Johann</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kiechl</LastName><ForeName>Stefan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Willeit</LastName><ForeName>Karin</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mason</LastName><ForeName>Dan</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Bradford Institute for Health Research, Bradford Royal Infirmary, Bradford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wright</LastName><ForeName>John</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Bradford Institute for Health Research, Bradford Royal Infirmary, Bradford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morris</LastName><ForeName>Richard</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>School of Social and Community Medicine, University of Bristol, Bristol, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wanamethee</LastName><ForeName>Goya</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Primary Care & Population Health, University College London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Whincup</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Population Health Research Institute, St George's, University of London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ben-Shlomo</LastName><ForeName>Yoav</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>School of Social and Community Medicine, University of Bristol, Bristol, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McLachlan</LastName><ForeName>Stela</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Price</LastName><ForeName>Jackie F</ForeName><Initials>JF</Initials><AffiliationInfo><Affiliation>Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kivimaki</LastName><ForeName>Mika</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Welch</LastName><ForeName>Catherine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sanchez-Galvez</LastName><ForeName>Adelaida</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marques-Vidal</LastName><ForeName>Pedro</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Internal Medicine Unit, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nicolaides</LastName><ForeName>Andrew</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Vascular Surgery, Imperial College London, London, UK; Department of Surgery, Nicosia Medical School, University of Nicosia, Nicosia, Cyprus.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Panayiotou</LastName><ForeName>Andrie G</ForeName><Initials>AG</Initials><AffiliationInfo><Affiliation>Cyprus International Institute for Environmental and Public Health, Cyprus University of Technology, Limassol, Cyprus.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Onland-Moret</LastName><ForeName>N Charlotte</ForeName><Initials>NC</Initials><AffiliationInfo><Affiliation>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van der Schouw</LastName><ForeName>Yvonne T</ForeName><Initials>YT</Initials><AffiliationInfo><Affiliation>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Matullo</LastName><ForeName>Giuseppe</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Human Genetics Foundation, HuGeF, Turin, Italy; Department of Medical Sciences, University of Turin, Turin, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fiorito</LastName><ForeName>Giovanni</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Human Genetics Foundation, HuGeF, Turin, Italy; Department of Medical Sciences, University of Turin, Turin, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guarrera</LastName><ForeName>Simonetta</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Human Genetics Foundation, HuGeF, Turin, Italy; Department of Medical Sciences, University of Turin, Turin, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sacerdote</LastName><ForeName>Carlotta</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Cancer Epidemiology Unit, San Giovanni Battista Hospital, Turin, Italy; Centre for Oncology Prevention, CPO Piemonte, Turin, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wareham</LastName><ForeName>Nicholas J</ForeName><Initials>NJ</Initials><AffiliationInfo><Affiliation>MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Langenberg</LastName><ForeName>Claudia</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Scott</LastName><ForeName>Robert</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Luan</LastName><ForeName>Jian'an</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bobak</LastName><ForeName>Martin</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Malyutina</LastName><ForeName>Sofia</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Novosibirsk State Medical University, Novosibirsk, Russia; Institute of Internal and Preventive Medicine, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pająk</LastName><ForeName>Andrzej</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Jagiellonian University Collegium Medicum, Krakow, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kubinova</LastName><ForeName>Ruzena</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>National Institute of Public Health, Prague, Czech Republic.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tamosiunas</LastName><ForeName>Abdonas</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Lithuanian University of Health Sciences, Kaunas, Lithuania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pikhart</LastName><ForeName>Hynek</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Husemoen</LastName><ForeName>Lise Lotte Nystrup</ForeName><Initials>LL</Initials><AffiliationInfo><Affiliation>Research Centre for Prevention and Health, Capital Region of Denmark, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grarup</LastName><ForeName>Niels</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pedersen</LastName><ForeName>Oluf</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hansen</LastName><ForeName>Torben</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Linneberg</LastName><ForeName>Allan</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Research Centre for Prevention and Health, Capital Region of Denmark, Denmark; Department of Clinical Experimental Research, Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Simonsen</LastName><ForeName>Kenneth Starup</ForeName><Initials>KS</Initials><AffiliationInfo><Affiliation>Research Centre for Prevention and Health, Capital Region of Denmark, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cooper</LastName><ForeName>Jackie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Centre for Cardiovascular Genetics, University College London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Humphries</LastName><ForeName>Steve E</ForeName><Initials>SE</Initials><AffiliationInfo><Affiliation>Centre for Cardiovascular Genetics, University College London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brilliant</LastName><ForeName>Murray</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, WI, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kitchner</LastName><ForeName>Terrie</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, WI, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hakonarson</LastName><ForeName>Hakon</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Children's Hospital of Philadelphia, Philadelphia, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carrell</LastName><ForeName>David S</ForeName><Initials>DS</Initials><AffiliationInfo><Affiliation>Group Health Research Institute in Seattle, WA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McCarty</LastName><ForeName>Catherine A</ForeName><Initials>CA</Initials><AffiliationInfo><Affiliation>Essentia Institute of Rural Health, Duluth, MN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kirchner</LastName><ForeName>H Lester</ForeName><Initials>HL</Initials><AffiliationInfo><Affiliation>Center for Health Research, Geisinger Clinic, Danville, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Larson</LastName><ForeName>Eric B</ForeName><Initials>EB</Initials><AffiliationInfo><Affiliation>Group Health Research Institute, Seattle, WA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Crosslin</LastName><ForeName>David R</ForeName><Initials>DR</Initials><AffiliationInfo><Affiliation>Group Health Research Institute, Seattle, WA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Andrade</LastName><ForeName>Mariza</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Roden</LastName><ForeName>Dan M</ForeName><Initials>DM</Initials><AffiliationInfo><Affiliation>Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Denny</LastName><ForeName>Joshua C</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carty</LastName><ForeName>Cara</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>George Washington University, Washington, DC, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hancock</LastName><ForeName>Stephen</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>University of Newcastle, Newcastle, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Attia</LastName><ForeName>John</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>University of Newcastle, Newcastle, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Holliday</LastName><ForeName>Elizabeth</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>University of Newcastle, Newcastle, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>O'Donnell</LastName><ForeName>Martin</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Population Health Research Institute, Hamilton, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yusuf</LastName><ForeName>Salim</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Population Health Research Institute, Hamilton, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chong</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Population Health Research Institute, Hamilton, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pare</LastName><ForeName>Guillaume</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Population Health Research Institute, Hamilton, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van der Harst</LastName><ForeName>Pim</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Durrer Center for Cardiovascular Research, Netherlands Heart Institute, Utrecht, Netherlands; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Said</LastName><ForeName>M Abdullah</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eppinga</LastName><ForeName>Ruben N</ForeName><Initials>RN</Initials><AffiliationInfo><Affiliation>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Verweij</LastName><ForeName>Niek</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Snieder</LastName><ForeName>Harold</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>LifeLines Cohort study group</CollectiveName></Author><Author ValidYN="Y"><LastName>Christen</LastName><ForeName>Tim</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mook-Kanamori</LastName><ForeName>Dennis O</ForeName><Initials>DO</Initials><AffiliationInfo><Affiliation>Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gustafsson</LastName><ForeName>Stefan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lind</LastName><ForeName>Lars</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ingelsson</LastName><ForeName>Erik</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden; Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pazoki</LastName><ForeName>Raha</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Franco</LastName><ForeName>Oscar</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hofman</LastName><ForeName>Albert</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Uitterlinden</LastName><ForeName>Andre</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dehghan</LastName><ForeName>Abbas</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Faculty of Medicine, and Department of Biostatistics and Epidemiology, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Teumer</LastName><ForeName>Alexander</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany; German Centre for Cardiovascular Research (DZHK), Greifswald, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Baumeister</LastName><ForeName>Sebastian</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany; Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dörr</LastName><ForeName>Marcus</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany; German Centre for Cardiovascular Research (DZHK), Greifswald, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lerch</LastName><ForeName>Markus M</ForeName><Initials>MM</Initials><AffiliationInfo><Affiliation>Department of Medicine A, University Medicine Greifswald, Greifswald, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Völker</LastName><ForeName>Uwe</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Interfaculty Institute of Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany; German Centre for Cardiovascular Research (DZHK), Greifswald, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Völzke</LastName><ForeName>Henry</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany; German Centre for Cardiovascular Research (DZHK), Greifswald, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ward</LastName><ForeName>Joey</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Institute of Health & Wellbeing, University of Glasgow, Glasgow, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pell</LastName><ForeName>Jill P</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>Institute of Health & Wellbeing, University of Glasgow, Glasgow, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smith</LastName><ForeName>Daniel J</ForeName><Initials>DJ</Initials><AffiliationInfo><Affiliation>Institute of Health & Wellbeing, University of Glasgow, Glasgow, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Meade</LastName><ForeName>Tom</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Non-Communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maitland-van der Zee</LastName><ForeName>Anke H</ForeName><Initials>AH</Initials><AffiliationInfo><Affiliation>Department of Respiratory Medicine, Academic Medical Center Amsterdam, Netherlands; Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Baranova</LastName><ForeName>Ekaterina V</ForeName><Initials>EV</Initials><AffiliationInfo><Affiliation>Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Young</LastName><ForeName>Robin</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ford</LastName><ForeName>Ian</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Campbell</LastName><ForeName>Archie</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Padmanabhan</LastName><ForeName>Sandosh</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bots</LastName><ForeName>Michiel L</ForeName><Initials>ML</Initials><AffiliationInfo><Affiliation>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grobbee</LastName><ForeName>Diederick E</ForeName><Initials>DE</Initials><AffiliationInfo><Affiliation>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Froguel</LastName><ForeName>Philippe</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Genomics of Common Disease, Imperial College London, London, UK; CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thuillier</LastName><ForeName>Dorothée</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Balkau</LastName><ForeName>Beverley</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Renal and Cardiovascular Epidemiology, Centre de Recherche en Epidémiologie et Santé des Populations (CESP), INSERM U1018, Villejuif, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bonnefond</LastName><ForeName>Amélie</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Genomics of Common Disease, Imperial College London, London, UK; CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cariou</LastName><ForeName>Bertrand</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>I'institut du Thorax, INSERM, CNRS, University of Nantes, CHU de Nantes, Nantes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smart</LastName><ForeName>Melissa</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institute for Social and Economic Research, University of Essex, Colchester, Essex, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bao</LastName><ForeName>Yanchun</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Institute for Social and Economic Research, University of Essex, Colchester, Essex, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kumari</LastName><ForeName>Meena</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institute for Social and Economic Research, University of Essex, Colchester, Essex, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mahajan</LastName><ForeName>Anubha</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ridker</LastName><ForeName>Paul M</ForeName><Initials>PM</Initials><AffiliationInfo><Affiliation>Harvard Medical School Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chasman</LastName><ForeName>Daniel I</ForeName><Initials>DI</Initials><AffiliationInfo><Affiliation>Harvard Medical School Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Reiner</LastName><ForeName>Alex P</ForeName><Initials>AP</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lange</LastName><ForeName>Leslie A</ForeName><Initials>LA</Initials><AffiliationInfo><Affiliation>Anschutz Medical Campus, University of Colorado Denver, Denver, CO, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ritchie</LastName><ForeName>Marylyn D</ForeName><Initials>MD</Initials><AffiliationInfo><Affiliation>Biomedical and Translational Informatics, Geisinger Health System, Danville, PA, USA; Department of Biochemistry and Molecular Biology, Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Asselbergs</LastName><ForeName>Folkert W</ForeName><Initials>FW</Initials><AffiliationInfo><Affiliation>Institute of Cardiovascular Science, University College London, UK; Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London, UK; Durrer Center for Cardiovascular Research, Netherlands Heart Institute, Utrecht, Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands; Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Casas</LastName><ForeName>Juan-Pablo</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Keating</LastName><ForeName>Brendan J</ForeName><Initials>BJ</Initials><AffiliationInfo><Affiliation>Department of Surgery, University of Pennsylvania, Philadelphia, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Preiss</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK; Medical Research Council Population Health Research Unit at the University of Oxford, University of Oxford, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hingorani</LastName><ForeName>Aroon D</ForeName><Initials>AD</Initials><AffiliationInfo><Affiliation>Institute of Cardiovascular Science, University College London, UK; Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>UCLEB consortium</CollectiveName></Author><Author ValidYN="Y"><LastName>Sattar</LastName><ForeName>Naveed</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK. Electronic address: naveed.sattar@glasgow.ac.uk.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>G1001799</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>RG/08/008/25291</GrantID><Agency>British Heart Foundation</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>MR/K006665/1</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>PG/13/66/30442</GrantID><Agency>British Heart Foundation</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>G0802432</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>MC_PC_13042</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>RG/08/013/25942</GrantID><Agency>British Heart Foundation</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>MC_UU_12015/1</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>CZD/16/6/4</GrantID><Agency>Chief Scientist Office</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>MR/K006584/1</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>MR/K013351/1</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>PG/12/71/29684</GrantID><Agency>British Heart Foundation</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>RG/13/16/30528</GrantID><Agency>British Heart Foundation</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>R01 HL135313</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 HG008701</GrantID><Acronym>HG</Acronym><Agency>NHGRI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>FS/14/76/30933</GrantID><Agency>British Heart Foundation</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>RG/10/12/28456</GrantID><Agency>British Heart Foundation</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>11</Month><Day>29</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Lancet Diabetes Endocrinol</MedlineTA><NlmUniqueID>101618821</NlmUniqueID><ISSNLinking>2213-8587</ISSNLinking></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Diabetes. 2010 Dec;59(12):3229-39</RefSource><PMID Version="1">20858683</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2013 Nov;45(11):1274-83</RefSource><PMID 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PubStatus="accepted"><Year>2016</Year><Month>11</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>12</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>12</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>12</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27908689</ArticleId><ArticleId IdType="pii">S2213-8587(16)30396-5</ArticleId><ArticleId IdType="doi">10.1016/S2213-8587(16)30396-5</ArticleId><ArticleId IdType="pmc">PMC5266795</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Autriche</li><li>Brésil</li><li>Canada</li><li>Chypre (pays)</li><li>Danemark</li><li>France</li><li>Italie</li><li>Lituanie</li><li>Pays-Bas</li><li>Pologne</li><li>Royaume-Uni</li><li>Russie</li><li>République tchèque</li><li>Suisse</li><li>Suède</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Berlin</li><li>Bohême centrale</li><li>Californie</li><li>Canton de Vaud</li><li>Colorado</li><li>District de Columbia</li><li>East Middle Sweden</li><li>Grand Londres</li><li>Groningue (province)</li><li>Hauts-de-France</li><li>Hollande-Méridionale</li><li>Hovedstaden</li><li>Massachusetts</li><li>Minnesota</li><li>Nord-Pas-de-Calais</li><li>Oxfordshire</li><li>Pays de la Loire</li><li>Pennsylvanie</li><li>Piémont</li><li>Svealand</li><li>Tennessee</li><li>Tyrol (Land)</li><li>Utrecht (province)</li><li>Washington 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Schmidt</name></region><name sortKey="Bao, Yanchun" sort="Bao, Yanchun" uniqKey="Bao Y" first="Yanchun" last="Bao">Yanchun Bao</name><name sortKey="Ben Shlomo, Yoav" sort="Ben Shlomo, Yoav" uniqKey="Ben Shlomo Y" first="Yoav" last="Ben-Shlomo">Yoav Ben-Shlomo</name><name sortKey="Bobak, Martin" sort="Bobak, Martin" uniqKey="Bobak M" first="Martin" last="Bobak">Martin Bobak</name><name sortKey="Campbell, Archie" sort="Campbell, Archie" uniqKey="Campbell A" first="Archie" last="Campbell">Archie Campbell</name><name sortKey="Casas, Juan Pablo" sort="Casas, Juan Pablo" uniqKey="Casas J" first="Juan-Pablo" last="Casas">Juan-Pablo Casas</name><name sortKey="Cooper, Jackie" sort="Cooper, Jackie" uniqKey="Cooper J" first="Jackie" last="Cooper">Jackie Cooper</name><name sortKey="Fairhurst Hunter, Zammy" sort="Fairhurst Hunter, Zammy" uniqKey="Fairhurst Hunter Z" first="Zammy" last="Fairhurst-Hunter">Zammy Fairhurst-Hunter</name><name sortKey="Ford, Ian" sort="Ford, Ian" uniqKey="Ford I" first="Ian" last="Ford">Ian Ford</name><name sortKey="Hingorani, Aroon D" sort="Hingorani, Aroon D" uniqKey="Hingorani A" first="Aroon D" last="Hingorani">Aroon D. Hingorani</name><name sortKey="Holmes, Michael V" sort="Holmes, Michael V" uniqKey="Holmes M" first="Michael V" last="Holmes">Michael V. Holmes</name><name sortKey="Humphries, Steve E" sort="Humphries, Steve E" uniqKey="Humphries S" first="Steve E" last="Humphries">Steve E. Humphries</name><name sortKey="Kivimaki, Mika" sort="Kivimaki, Mika" uniqKey="Kivimaki M" first="Mika" last="Kivimaki">Mika Kivimaki</name><name sortKey="Kumari, Meena" sort="Kumari, Meena" uniqKey="Kumari M" first="Meena" last="Kumari">Meena Kumari</name><name sortKey="Langenberg, Claudia" sort="Langenberg, Claudia" uniqKey="Langenberg C" first="Claudia" last="Langenberg">Claudia Langenberg</name><name sortKey="Luan, Jian An" sort="Luan, Jian An" uniqKey="Luan J" first="Jian'An" last="Luan">Jian'An Luan</name><name sortKey="Lyall, Donald M" sort="Lyall, Donald M" uniqKey="Lyall D" first="Donald M" last="Lyall">Donald M. Lyall</name><name sortKey="Mahajan, Anubha" sort="Mahajan, Anubha" uniqKey="Mahajan A" first="Anubha" last="Mahajan">Anubha Mahajan</name><name sortKey="Mason, Dan" sort="Mason, Dan" uniqKey="Mason D" first="Dan" last="Mason">Dan Mason</name><name sortKey="Mclachlan, Stela" sort="Mclachlan, Stela" uniqKey="Mclachlan S" first="Stela" last="Mclachlan">Stela Mclachlan</name><name sortKey="Meade, Tom" sort="Meade, Tom" uniqKey="Meade T" first="Tom" last="Meade">Tom Meade</name><name sortKey="Morris, Richard" sort="Morris, Richard" uniqKey="Morris R" first="Richard" last="Morris">Richard Morris</name><name sortKey="Padmanabhan, Sandosh" sort="Padmanabhan, Sandosh" uniqKey="Padmanabhan S" first="Sandosh" last="Padmanabhan">Sandosh Padmanabhan</name><name sortKey="Patel, Riyaz S" sort="Patel, Riyaz S" uniqKey="Patel R" first="Riyaz S" last="Patel">Riyaz S. Patel</name><name sortKey="Pell, Jill P" sort="Pell, Jill P" uniqKey="Pell J" first="Jill P" last="Pell">Jill P. Pell</name><name sortKey="Pikhart, Hynek" sort="Pikhart, Hynek" uniqKey="Pikhart H" first="Hynek" last="Pikhart">Hynek Pikhart</name><name sortKey="Power, Christine" sort="Power, Christine" uniqKey="Power C" first="Christine" last="Power">Christine Power</name><name sortKey="Preiss, David" sort="Preiss, David" uniqKey="Preiss D" first="David" last="Preiss">David Preiss</name><name sortKey="Price, Jackie F" sort="Price, Jackie F" uniqKey="Price J" first="Jackie F" last="Price">Jackie F. Price</name><name sortKey="Sanchez Galvez, Adelaida" sort="Sanchez Galvez, Adelaida" uniqKey="Sanchez Galvez A" first="Adelaida" last="Sanchez-Galvez">Adelaida Sanchez-Galvez</name><name sortKey="Sattar, Naveed" sort="Sattar, Naveed" uniqKey="Sattar N" first="Naveed" last="Sattar">Naveed Sattar</name><name sortKey="Scott, Robert" sort="Scott, Robert" uniqKey="Scott R" first="Robert" last="Scott">Robert Scott</name><name sortKey="Smart, Melissa" sort="Smart, Melissa" uniqKey="Smart M" first="Melissa" last="Smart">Melissa Smart</name><name sortKey="Smith, Daniel J" sort="Smith, Daniel J" uniqKey="Smith D" first="Daniel J" last="Smith">Daniel J. Smith</name><name sortKey="Swerdlow, Daniel I" sort="Swerdlow, Daniel I" uniqKey="Swerdlow D" first="Daniel I" last="Swerdlow">Daniel I. Swerdlow</name><name sortKey="Wanamethee, Goya" sort="Wanamethee, Goya" uniqKey="Wanamethee G" first="Goya" last="Wanamethee">Goya Wanamethee</name><name sortKey="Ward, Joey" sort="Ward, Joey" uniqKey="Ward J" first="Joey" last="Ward">Joey Ward</name><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J" last="Wareham">Nicholas J. Wareham</name><name sortKey="Welch, Catherine" sort="Welch, Catherine" uniqKey="Welch C" first="Catherine" last="Welch">Catherine Welch</name><name sortKey="Whincup, Peter" sort="Whincup, Peter" uniqKey="Whincup P" first="Peter" last="Whincup">Peter Whincup</name><name sortKey="Wright, John" sort="Wright, John" uniqKey="Wright J" first="John" last="Wright">John Wright</name><name sortKey="Young, Robin" sort="Young, Robin" uniqKey="Young R" first="Robin" last="Young">Robin Young</name></country><country name="Brésil"><noRegion><name sortKey="Hartwig, Fernando Pires" sort="Hartwig, Fernando Pires" uniqKey="Hartwig F" first="Fernando Pires" last="Hartwig">Fernando Pires Hartwig</name></noRegion><name sortKey="Horta, Bernardo Lessa" sort="Horta, Bernardo Lessa" uniqKey="Horta B" first="Bernardo Lessa" last="Horta">Bernardo Lessa Horta</name></country><country name="Australie"><noRegion><name sortKey="Hypponen, Elina" sort="Hypponen, Elina" uniqKey="Hypponen E" first="Elina" last="Hyppönen">Elina Hyppönen</name></noRegion><name sortKey="Attia, John" sort="Attia, John" uniqKey="Attia J" first="John" last="Attia">John Attia</name><name sortKey="Hancock, Stephen" sort="Hancock, Stephen" uniqKey="Hancock S" first="Stephen" last="Hancock">Stephen Hancock</name><name sortKey="Holliday, Elizabeth" sort="Holliday, Elizabeth" uniqKey="Holliday E" first="Elizabeth" last="Holliday">Elizabeth Holliday</name><name sortKey="Moldovan, Max" sort="Moldovan, Max" uniqKey="Moldovan M" first="Max" last="Moldovan">Max Moldovan</name></country><country name="Pays-Bas"><noRegion><name sortKey="Van Iperen, Erik" sort="Van Iperen, Erik" uniqKey="Van Iperen E" first="Erik" last="Van Iperen">Erik Van Iperen</name></noRegion><name sortKey="Asselbergs, Folkert W" sort="Asselbergs, Folkert W" uniqKey="Asselbergs F" first="Folkert W" last="Asselbergs">Folkert W. Asselbergs</name><name sortKey="Baranova, Ekaterina V" sort="Baranova, Ekaterina V" uniqKey="Baranova E" first="Ekaterina V" last="Baranova">Ekaterina V. Baranova</name><name sortKey="Bots, Michiel L" sort="Bots, Michiel L" uniqKey="Bots M" first="Michiel L" last="Bots">Michiel L. Bots</name><name sortKey="Christen, Tim" sort="Christen, Tim" uniqKey="Christen T" first="Tim" last="Christen">Tim Christen</name><name sortKey="Dehghan, Abbas" sort="Dehghan, Abbas" uniqKey="Dehghan A" first="Abbas" last="Dehghan">Abbas Dehghan</name><name sortKey="Eppinga, Ruben N" sort="Eppinga, Ruben N" uniqKey="Eppinga R" first="Ruben N" last="Eppinga">Ruben N. Eppinga</name><name sortKey="Franco, Oscar" sort="Franco, Oscar" uniqKey="Franco O" first="Oscar" last="Franco">Oscar Franco</name><name sortKey="Grobbee, Diederick E" sort="Grobbee, Diederick E" uniqKey="Grobbee D" first="Diederick E" last="Grobbee">Diederick E. Grobbee</name><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><name sortKey="Hovingh, G Kees" sort="Hovingh, G Kees" uniqKey="Hovingh G" first="G Kees" last="Hovingh">G Kees Hovingh</name><name sortKey="Maitland Van Der Zee, Anke H" sort="Maitland Van Der Zee, Anke H" uniqKey="Maitland Van Der Zee A" first="Anke H" last="Maitland-Van Der Zee">Anke H. Maitland-Van Der Zee</name><name sortKey="Mook Kanamori, Dennis O" sort="Mook Kanamori, Dennis O" uniqKey="Mook Kanamori D" first="Dennis O" last="Mook-Kanamori">Dennis O. Mook-Kanamori</name><name sortKey="Onland Moret, N Charlotte" sort="Onland Moret, N Charlotte" uniqKey="Onland Moret N" first="N Charlotte" last="Onland-Moret">N Charlotte Onland-Moret</name><name sortKey="Pazoki, Raha" sort="Pazoki, Raha" uniqKey="Pazoki R" first="Raha" last="Pazoki">Raha Pazoki</name><name sortKey="Said, M Abdullah" sort="Said, M Abdullah" uniqKey="Said M" first="M Abdullah" last="Said">M Abdullah Said</name><name sortKey="Snieder, Harold" sort="Snieder, Harold" uniqKey="Snieder H" first="Harold" last="Snieder">Harold Snieder</name><name sortKey="Uitterlinden, Andre" sort="Uitterlinden, Andre" uniqKey="Uitterlinden A" first="Andre" last="Uitterlinden">Andre Uitterlinden</name><name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name><name sortKey="Van Der Schouw, Yvonne T" sort="Van Der Schouw, Yvonne T" uniqKey="Van Der Schouw Y" first="Yvonne T" last="Van Der Schouw">Yvonne T. Van Der Schouw</name><name sortKey="Verweij, Niek" sort="Verweij, Niek" uniqKey="Verweij N" first="Niek" last="Verweij">Niek Verweij</name></country><country name="Allemagne"><region name="Berlin"><name sortKey="Demuth, Ilja" sort="Demuth, Ilja" uniqKey="Demuth I" first="Ilja" last="Demuth">Ilja Demuth</name></region><name sortKey="Baumeister, Sebastian" sort="Baumeister, Sebastian" uniqKey="Baumeister S" first="Sebastian" last="Baumeister">Sebastian Baumeister</name><name sortKey="Bertram, Lars" sort="Bertram, Lars" uniqKey="Bertram L" first="Lars" last="Bertram">Lars Bertram</name><name sortKey="Demuth, Juri" sort="Demuth, Juri" uniqKey="Demuth J" first="Juri" last="Demuth">Juri Demuth</name><name sortKey="Dorr, Marcus" sort="Dorr, Marcus" uniqKey="Dorr M" first="Marcus" last="Dörr">Marcus Dörr</name><name sortKey="Lerch, Markus M" sort="Lerch, Markus M" uniqKey="Lerch M" first="Markus M" last="Lerch">Markus M. Lerch</name><name sortKey="Liu, Tian" sort="Liu, Tian" uniqKey="Liu T" first="Tian" last="Liu">Tian Liu</name><name sortKey="Norman, Kristina" sort="Norman, Kristina" uniqKey="Norman K" first="Kristina" last="Norman">Kristina Norman</name><name sortKey="Steinhagen Thiessen, Elisabeth" sort="Steinhagen Thiessen, Elisabeth" uniqKey="Steinhagen Thiessen E" first="Elisabeth" last="Steinhagen-Thiessen">Elisabeth Steinhagen-Thiessen</name><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name><name sortKey="Volker, Uwe" sort="Volker, Uwe" uniqKey="Volker U" first="Uwe" last="Völker">Uwe Völker</name><name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name></country><country name="Autriche"><region name="Tyrol (Land)"><name sortKey="Coassin, Stefan" sort="Coassin, Stefan" uniqKey="Coassin S" first="Stefan" last="Coassin">Stefan Coassin</name></region><name sortKey="Kiechl, Stefan" sort="Kiechl, Stefan" uniqKey="Kiechl S" first="Stefan" last="Kiechl">Stefan Kiechl</name><name sortKey="Willeit, Johann" sort="Willeit, Johann" uniqKey="Willeit J" first="Johann" last="Willeit">Johann Willeit</name><name sortKey="Willeit, Karin" sort="Willeit, Karin" uniqKey="Willeit K" first="Karin" last="Willeit">Karin Willeit</name></country><country name="Suisse"><region name="Canton de Vaud"><name sortKey="Marques Vidal, Pedro" sort="Marques Vidal, Pedro" uniqKey="Marques Vidal P" first="Pedro" last="Marques-Vidal">Pedro Marques-Vidal</name></region></country><country name="Chypre (pays)"><noRegion><name sortKey="Nicolaides, Andrew" sort="Nicolaides, Andrew" uniqKey="Nicolaides A" first="Andrew" last="Nicolaides">Andrew Nicolaides</name></noRegion><name sortKey="Panayiotou, Andrie G" sort="Panayiotou, Andrie G" uniqKey="Panayiotou A" first="Andrie G" last="Panayiotou">Andrie G. 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Carrell</name><name sortKey="Carty, Cara" sort="Carty, Cara" uniqKey="Carty C" first="Cara" last="Carty">Cara Carty</name><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I" last="Chasman">Daniel I. Chasman</name><name sortKey="Crosslin, David R" sort="Crosslin, David R" uniqKey="Crosslin D" first="David R" last="Crosslin">David R. Crosslin</name><name sortKey="De Andrade, Mariza" sort="De Andrade, Mariza" uniqKey="De Andrade M" first="Mariza" last="De Andrade">Mariza De Andrade</name><name sortKey="Denny, Joshua C" sort="Denny, Joshua C" uniqKey="Denny J" first="Joshua C" last="Denny">Joshua C. Denny</name><name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name><name sortKey="Ingelsson, Erik" sort="Ingelsson, Erik" uniqKey="Ingelsson E" first="Erik" last="Ingelsson">Erik Ingelsson</name><name sortKey="Keating, Brendan J" sort="Keating, Brendan J" uniqKey="Keating B" first="Brendan J" last="Keating">Brendan J. Keating</name><name sortKey="Kirchner, H Lester" sort="Kirchner, H Lester" uniqKey="Kirchner H" first="H Lester" last="Kirchner">H Lester Kirchner</name><name sortKey="Kitchner, Terrie" sort="Kitchner, Terrie" uniqKey="Kitchner T" first="Terrie" last="Kitchner">Terrie Kitchner</name><name sortKey="Lange, Leslie A" sort="Lange, Leslie A" uniqKey="Lange L" first="Leslie A" last="Lange">Leslie A. Lange</name><name sortKey="Larson, Eric B" sort="Larson, Eric B" uniqKey="Larson E" first="Eric B" last="Larson">Eric B. Larson</name><name sortKey="Mccarty, Catherine A" sort="Mccarty, Catherine A" uniqKey="Mccarty C" first="Catherine A" last="Mccarty">Catherine A. Mccarty</name><name sortKey="Reiner, Alex P" sort="Reiner, Alex P" uniqKey="Reiner A" first="Alex P" last="Reiner">Alex P. Reiner</name><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M" last="Ridker">Paul M. Ridker</name><name sortKey="Ritchie, Marylyn D" sort="Ritchie, Marylyn D" uniqKey="Ritchie M" first="Marylyn D" last="Ritchie">Marylyn D. Ritchie</name><name sortKey="Roden, Dan M" sort="Roden, Dan M" uniqKey="Roden D" first="Dan M" last="Roden">Dan M. Roden</name></country><country name="Canada"><noRegion><name sortKey="O Donnell, Martin" sort="O Donnell, Martin" uniqKey="O Donnell M" first="Martin" last="O'Donnell">Martin O'Donnell</name></noRegion><name sortKey="Chong, Michael" sort="Chong, Michael" uniqKey="Chong M" first="Michael" last="Chong">Michael Chong</name><name sortKey="Pare, Guillaume" sort="Pare, Guillaume" uniqKey="Pare G" first="Guillaume" last="Pare">Guillaume Pare</name><name sortKey="Yusuf, Salim" sort="Yusuf, Salim" uniqKey="Yusuf S" first="Salim" last="Yusuf">Salim Yusuf</name></country><country name="Suède"><region name="Svealand"><name sortKey="Gustafsson, Stefan" sort="Gustafsson, Stefan" uniqKey="Gustafsson S" first="Stefan" last="Gustafsson">Stefan Gustafsson</name></region><name sortKey="Lind, Lars" sort="Lind, Lars" uniqKey="Lind L" first="Lars" last="Lind">Lars Lind</name></country><country name="France"><region name="Hauts-de-France"><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name></region><name sortKey="Balkau, Beverley" sort="Balkau, Beverley" uniqKey="Balkau B" first="Beverley" last="Balkau">Beverley Balkau</name><name sortKey="Bonnefond, Amelie" sort="Bonnefond, Amelie" uniqKey="Bonnefond A" first="Amélie" last="Bonnefond">Amélie Bonnefond</name><name sortKey="Cariou, Bertrand" sort="Cariou, Bertrand" uniqKey="Cariou B" first="Bertrand" last="Cariou">Bertrand Cariou</name><name sortKey="Thuillier, Dorothee" sort="Thuillier, Dorothee" uniqKey="Thuillier D" first="Dorothée" last="Thuillier">Dorothée Thuillier</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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